{"id":"1723d808-f3f7-5e01-87d3-2c140db94297","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-nact-human","predicate":"stimulates","statement":"Lithium stimulated human NaCT-mediated citrate transport at concentrations relevant to prescription exposure.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"76060bf0-fb57-5512-aef7-61a40af64e22","mechanism_event_label":"A sodium-coupled carrier links lithium to carbon metabolism.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"68eeb90a-bbc5-5bc8-8346-31029ed0d815","slug":"slc13a5","display_name":"Human sodium-coupled citrate transporter / SLC13A5","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"76060bf0-fb57-5512-aef7-61a40af64e22","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-nact-human-event","event_type":"observed_relationship","label":"A sodium-coupled carrier links lithium to carbon metabolism.","description":"Lithium stimulated human NaCT-mediated citrate transport at concentrations relevant to prescription exposure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"68eeb90a-bbc5-5bc8-8346-31029ed0d815","slug":"slc13a5","display_name":"Human sodium-coupled citrate transporter / SLC13A5","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"1c54abac-4dfd-5303-b0f4-37945245e18e","slug":"citrate","display_name":"Citrate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Expressed human transporter and human liver-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence that trace lithium has the same effect or that citrate salt ingestion determines the response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A sodium-coupled carrier links lithium to carbon metabolism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12826022/ · DOI 10.1042/BJ20030827","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6a2ce31f-5c56-591b-9889-c3445e4c7e6a","evidence_kind":"source_excerpt","locator":"Lines 264-270","start_line":264,"end_line":270,"excerpt":"## lithium-nact-human\nA sodium-coupled carrier links lithium to carbon metabolism.\nLithium stimulated human NaCT-mediated citrate transport at concentrations relevant to prescription exposure.\nModel: Expressed human transporter and human liver-cell experiments.\nLimitations: Not evidence that trace lithium has the same effect or that citrate salt ingestion determines the response.\nEvidence access: Primary abstract\nHuman sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12826022/ · DOI 10.1042/BJ20030827","model_system":"Expressed human transporter and human liver-cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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