{"id":"172285c6-ff49-55e0-b903-b27b73dff280","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-vitamin-e-replacement","predicate":"fails_to_replace","statement":"Feeding vitamin-E-deficient rats 100 mg myricetin/kg diet for two weeks did not significantly improve the reported lipid-peroxidation and tissue-damage indices, unlike alpha-tocopherol repletion.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"415ef885-0f12-5fe0-a2cb-61fb03da228c","mechanism_event_label":"Myricetin did not function as a substitute for vitamin E in this model.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"9a6d304f-3787-5cc5-b01b-fed65cd3af5b","slug":"rat-vitamin-e-deficient-lipid-peroxidation","display_name":"Rat vitamin-E-deficient lipid peroxidation and tissue-injury indices","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"415ef885-0f12-5fe0-a2cb-61fb03da228c","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-vitamin-e-replacement-event","event_type":"observed_relationship","label":"Myricetin did not function as a substitute for vitamin E in this model.","description":"Feeding vitamin-E-deficient rats 100 mg myricetin/kg diet for two weeks did not significantly improve the reported lipid-peroxidation and tissue-damage indices, unlike alpha-tocopherol repletion.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9a6d304f-3787-5cc5-b01b-fed65cd3af5b","slug":"rat-vitamin-e-deficient-lipid-peroxidation","display_name":"Rat vitamin-E-deficient lipid peroxidation and tissue-injury indices","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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