{"id":"16fa58f2-cef2-5a35-a9ca-1dae07447e62","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-insulin-pump","predicate":"aggravates_in_model","statement":"Slow-release insulin pumps worsened atherosclerosis in ApoE-null mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2363484a-e1e7-5b6c-8911-d9a804961cb1","mechanism_event_label":"A mediator intervention supported the proposed chain.","subject":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"object":{"id":"256296a9-0ea5-54bd-b890-202c0e427f64","slug":"apo-e-null-mouse-aspartame-atherosclerosis","display_name":"ApoE-null mouse atherosclerosis during aspartame exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2363484a-e1e7-5b6c-8911-d9a804961cb1","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-insulin-pump-event","event_type":"observed_relationship","label":"A mediator intervention supported the proposed chain.","description":"Slow-release insulin pumps worsened atherosclerosis in ApoE-null mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"256296a9-0ea5-54bd-b890-202c0e427f64","slug":"apo-e-null-mouse-aspartame-atherosclerosis","display_name":"ApoE-null mouse atherosclerosis during aspartame exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse insulin-pump experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not prove every aspartame effect is insulin-mediated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A mediator intervention supported the proposed chain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39978336/ · DOI 10.1016/j.cmet.2025.01.006","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c31d4d50-4fbc-511e-9734-659c7851765a","evidence_kind":"source_excerpt","locator":"Lines 266-272","start_line":266,"end_line":272,"excerpt":"## aspartame-insulin-pump\nA mediator intervention supported the proposed chain.\nSlow-release insulin pumps worsened atherosclerosis in ApoE-null mice.\nModel: Mouse insulin-pump experiment.\nLimitations: Does not prove every aspartame effect is insulin-mediated.\nEvidence access: Primary abstract\nSweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39978336/ · DOI 10.1016/j.cmet.2025.01.006","model_system":"Mouse insulin-pump experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"21cfc6808062c6ea1fb5d34128bcd005d31f0f6c0d63484794238db77d32ae97","revision_id":"1255dda8-df99-5d4b-a65b-4144c47d7d9b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}