{"id":"16ee1e5f-43ae-579c-a466-f0950dc1b16a","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-nrf2-translation","predicate":"promotes_translation_of","statement":"The prostate-cell study linked spermidine-driven eIF5A hypusination to increased NRF2 translation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4a9a7ff9-0501-579f-8dfd-adc3677bfbaa","mechanism_event_label":"A translation response can raise a stress regulator.","subject":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"object":{"id":"dc472dd3-d383-567a-ab37-a9ec4e112df4","slug":"nfe2l2","display_name":"Human Nrf2 / NFE2L2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"4a9a7ff9-0501-579f-8dfd-adc3677bfbaa","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-nrf2-translation-event","event_type":"observed_relationship","label":"A translation response can raise a stress regulator.","description":"The prostate-cell study linked spermidine-driven eIF5A hypusination to increased NRF2 translation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dc472dd3-d383-567a-ab37-a9ec4e112df4","slug":"nfe2l2","display_name":"Human Nrf2 / NFE2L2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fd7586aa-2477-5fbf-b715-1fd83e0c5483","slug":"eif5a1-hypusine","display_name":"eIF5A1 with hypusine at residue 50","entity_type_key":"protein_state"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human PC3/DU145 cells and hypusination perturbation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assay-specific pathway interpretation; does not mean NRF2 is always protective.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A translation response can raise a stress regulator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40486852/ · DOI 10.1016/j.apsb.2025.02.023","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5327e78a-333a-5dce-87f4-4bb2d33d14e0","evidence_kind":"source_excerpt","locator":"Lines 510-516","start_line":510,"end_line":516,"excerpt":"## spermidine-nrf2-translation\nA translation response can raise a stress regulator.\nThe prostate-cell study linked spermidine-driven eIF5A hypusination to increased NRF2 translation.\nModel: Human PC3/DU145 cells and hypusination perturbation.\nLimitations: Assay-specific pathway interpretation; does not mean NRF2 is always protective.\nEvidence access: Primary full text\nSpermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40486852/ · DOI 10.1016/j.apsb.2025.02.023","model_system":"Human PC3/DU145 cells and hypusination perturbation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4348f3f8-0180-58a3-b61c-55d03bb322d2","stable_key":"import-88eb7407-f147-558b-889b-0c89c4e0aa4a","title":"Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"8eec8784bc2bd0384cfd53c6603c4ced8e53c227d9ab29ed85594c43e34c68ef","revision_id":"7c421a18-4526-59f6-b84e-4be533bc35ac","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}