{"id":"1648e32c-80ab-5616-affb-e3adf1820340","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-tasl-recruitment","predicate":"recruits","statement":"Human SLC15A4 interacted with TASL and was required for its endolysosomal localization and function in the tested cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a66f051e-8b4a-5bb1-ba74-d9e9cfe2a179","mechanism_event_label":"The transporter also serves as a docking location for a signaling adaptor.","subject":{"id":"eca38509-73b3-5fc5-be33-2fa6d60ed1bb","slug":"slc15a4","display_name":"Human peptide/histidine transporter PHT1 / SLC15A4","entity_type_key":"protein"},"object":{"id":"82eae972-7da8-5908-bfd7-1d3c73e869ec","slug":"tasl","display_name":"Human TLR adaptor interacting with SLC15A4 / TASL","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"a66f051e-8b4a-5bb1-ba74-d9e9cfe2a179","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-tasl-recruitment-event","event_type":"observed_relationship","label":"The transporter also serves as a docking location for a signaling adaptor.","description":"Human SLC15A4 interacted with TASL and was required for its endolysosomal localization and function in the tested cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eca38509-73b3-5fc5-be33-2fa6d60ed1bb","slug":"slc15a4","display_name":"Human peptide/histidine transporter PHT1 / SLC15A4","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"82eae972-7da8-5908-bfd7-1d3c73e869ec","slug":"tasl","display_name":"Human TLR adaptor interacting with SLC15A4 / TASL","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary and transformed human immune cells; interaction mapping and mutagenesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Docking does not prove that the amount of histidine transported is the limiting signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The transporter also serves as a docking location for a signaling adaptor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32433612/ · DOI 10.1038/s41586-020-2282-0","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ae83a38e-0960-5788-8de5-33f485a01c71","evidence_kind":"source_excerpt","locator":"Lines 378-384","start_line":378,"end_line":384,"excerpt":"## histidine-tasl-recruitment\nThe transporter also serves as a docking location for a signaling adaptor.\nHuman SLC15A4 interacted with TASL and was required for its endolysosomal localization and function in the tested cells.\nModel: Primary and transformed human immune cells; interaction mapping and mutagenesis.\nLimitations: Docking does not prove that the amount of histidine transported is the limiting signal.\nEvidence access: Primary full text\nTASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32433612/ · DOI 10.1038/s41586-020-2282-0","model_system":"Primary and transformed human immune cells; interaction mapping and mutagenesis.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ce59e6c9-1213-523b-9d0b-400b7a81cd1c","stable_key":"import-911fb3c7-8cc3-5667-b677-5682fab67648","title":"L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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