{"id":"163a93cb-4dd2-5869-8f78-f545dc95257d","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-histone-mark","predicate":"increases","statement":"R-beta-hydroxybutyrate increased histone beta-hydroxybutyrylation despite absent detectable HDAC inhibition.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"30848495-2978-5239-8365-6f23eadb335d","mechanism_event_label":"A distinct histone modification can occur without proving the proposed HDAC route.","subject":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"object":{"id":"5891e38e-64aa-5b57-a71b-3a46b75f004c","slug":"histone-beta-hydroxybutyrylation","display_name":"Histone lysine beta-hydroxybutyrylation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"30848495-2978-5239-8365-6f23eadb335d","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-histone-mark-event","event_type":"observed_relationship","label":"A distinct histone modification can occur without proving the proposed HDAC route.","description":"R-beta-hydroxybutyrate increased histone beta-hydroxybutyrylation despite absent detectable HDAC inhibition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5891e38e-64aa-5b57-a71b-3a46b75f004c","slug":"histone-beta-hydroxybutyrylation","display_name":"Histone lysine beta-hydroxybutyrylation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cultured-cell comparison with butyrate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Beta-hydroxybutyrylation and acetylation are different modifications.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"A distinct histone modification can occur without proving the proposed HDAC route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30679586/ · DOI 10.1038/s41598-018-36941-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b899a608-1223-59c2-8543-ba2389a9af6f","evidence_kind":"source_excerpt","locator":"Lines 408-414","start_line":408,"end_line":414,"excerpt":"## fast-bhb-histone-mark\nA distinct histone modification can occur without proving the proposed HDAC route.\nR-beta-hydroxybutyrate increased histone beta-hydroxybutyrylation despite absent detectable HDAC inhibition.\nModel: Cultured-cell comparison with butyrate.\nLimitations: Beta-hydroxybutyrylation and acetylation are different modifications.\nEvidence access: Primary abstract\nProminent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30679586/ · DOI 10.1038/s41598-018-36941-9","model_system":"Cultured-cell comparison with butyrate.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}