{"id":"161a4314-887d-57b7-86ff-80e093178a49","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-microbiome-prediction","predicate":"associated_with_predicted_increase","statement":"Microbial-community models predicted higher agmatine-production capacity in metformin-treated cohorts, including longitudinal treatment data.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d0b8ec9d-02e7-5fdc-9e10-5445419cf3a7","mechanism_event_label":"The human evidence here concerns a modeled capacity rather than a measured causal mediator.","subject":{"id":"519971b1-5aef-5ad7-8022-840144855cd0","slug":"metformin","display_name":"Metformin","entity_type_key":"drug"},"object":{"id":"a1bc4447-35ab-5941-9e68-a7b5a18e70b2","slug":"human-modeled-microbial-agmatine-production","display_name":"Modeled human microbial agmatine-production capacity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d0b8ec9d-02e7-5fdc-9e10-5445419cf3a7","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-microbiome-prediction-event","event_type":"observed_relationship","label":"The human evidence here concerns a modeled capacity rather than a measured causal mediator.","description":"Microbial-community models predicted higher agmatine-production capacity in metformin-treated cohorts, including longitudinal treatment data.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"519971b1-5aef-5ad7-8022-840144855cd0","slug":"metformin","display_name":"Metformin","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a1bc4447-35ab-5941-9e68-a7b5a18e70b2","slug":"human-modeled-microbial-agmatine-production","display_name":"Modeled human microbial agmatine-production capacity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ae2dddf4-ce04-57e3-8a06-7ed9fdc24554","slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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