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(2006). https://pubmed.ncbi.nlm.nih.gov/16998128/ DOI: 10.1177/154405910608501005","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Whole-cell voltage-gated sodium current","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8d490e4f-5c38-524a-bb93-66d622b6358d","evidence_kind":"source_excerpt","locator":"Lines 44-53","start_line":44,"end_line":53,"excerpt":"## eugenol-dental-sodium-current\nEugenol inhibited action potentials and both tetrodotoxin-sensitive and resistant sodium currents in rat dental afferent neurons, and capsazepine did not prevent the current inhibition.\nModel/species: Retrogradely labeled rat dental primary afferent neurons\nTissue/system: Whole-cell voltage-gated sodium current\nExposure: Eugenol concentration-response with capsazepine\nRoute: In vitro\nDuration: Acute\nLimits: The sodium-current effect was TRPV1-independent in this assay; it does not specify a safe human pulp concentration.\nPrimary reference: Eugenol inhibits sodium currents in dental afferent neurons. (2006). https://pubmed.ncbi.nlm.nih.gov/16998128/ DOI: 10.1177/154405910608501005\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Retrogradely labeled rat dental primary afferent neurons","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f2ff5a4-7264-57fc-8368-46b9768ec668","stable_key":"import-2f309d3a-d252-5dfb-ae24-993a625f1b6c","title":"Eugenol: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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