{"id":"15f13af7-af0b-5bf9-96b6-76915eb70b1c","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-iv-phosphate","predicate":"reduces","statement":"The intravenous fructose bolus acutely lowered hepatic inorganic phosphate as sugar phosphates accumulated.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f4f355c3-400e-5ba8-8de2-1cca4acdd57f","mechanism_event_label":"The intravenous fructose bolus acutely lowered hepatic inorganic phosphate as sugar phosphates accumulated.","subject":{"id":"3c379840-5688-5b5d-84c0-5950b4fd8f17","slug":"fructose","display_name":"Fructose","entity_type_key":"small_molecule"},"object":{"id":"fe3eb840-db2a-5a02-85d4-80b0576cb71a","slug":"human-hepatic-inorganic-phosphate","display_name":"Human hepatic inorganic phosphate measured by phosphorus MRS","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f4f355c3-400e-5ba8-8de2-1cca4acdd57f","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-iv-phosphate-event","event_type":"observed_relationship","label":"The intravenous fructose bolus acutely lowered hepatic inorganic phosphate as sugar phosphates accumulated.","description":"The intravenous fructose bolus acutely lowered hepatic inorganic phosphate as sugar phosphates accumulated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3c379840-5688-5b5d-84c0-5950b4fd8f17","slug":"fructose","display_name":"Fructose","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fe3eb840-db2a-5a02-85d4-80b0576cb71a","slug":"human-hepatic-inorganic-phosphate","display_name":"Human hepatic inorganic phosphate measured by phosphorus MRS","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; protonation depends on pH)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a273c7f5-e73a-5464-8947-f2d52f201d88","slug":"fructose-1-phosphate","display_name":"D-Fructose 1-phosphate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Fructose 250 mg/kg bolus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Early 5 min changes; sugar-phosphate recovery within about 20 min","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Seven healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Isolated fructose, intravenous","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Injection bypasses the intestine. Magnitude cannot be assigned to a normal oral HFCS serving or to dietary phosphate deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Seven healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The intravenous fructose bolus acutely lowered hepatic inorganic phosphate as sugar phosphates accumulated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Assessment of human liver metabolism by phosphorus-31 magnetic resonance spectroscopy. (1986). https://pubmed.ncbi.nlm.nih.gov/3730768/ DOI: 10.1259/0007-1285-59-703-695","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Intravenous injection","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Liver phosphorus-31 MRS","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d720b1d6-d817-54d4-bf58-3f1506aecc2a","evidence_kind":"source_excerpt","locator":"Lines 245-255","start_line":245,"end_line":255,"excerpt":"## hfcs-iv-phosphate\nThe intravenous fructose bolus acutely lowered hepatic inorganic phosphate as sugar phosphates accumulated.\nModel/species: Seven healthy human volunteers\nTissue: Liver phosphorus-31 MRS\nExposure: Fructose 250 mg/kg bolus\nRoute: Intravenous injection\nDuration: Early 5 min changes; sugar-phosphate recovery within about 20 min\nExposure scope: Isolated fructose, intravenous\nLimits: Injection bypasses the intestine. Magnitude cannot be assigned to a normal oral HFCS serving or to dietary phosphate deficiency.\nReference: Assessment of human liver metabolism by phosphorus-31 magnetic resonance spectroscopy. (1986). https://pubmed.ncbi.nlm.nih.gov/3730768/ DOI: 10.1259/0007-1285-59-703-695\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"Seven healthy human volunteers","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e863ddf6-7c1e-5a70-8335-7f3ac3eeee92","stable_key":"import-c8c7aa13-14c6-5f5c-9afc-9217d0f2f736","title":"High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"f4721923a83b368d549ba110a4f8c8738026210b32f6d29f3bd3200aa420f3b3","revision_id":"45827d73-cb6d-5aff-969b-af364b74b168","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}