{"id":"15eef04f-eb3a-5698-810b-9db325377fad","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-heart-marker","predicate":"low_level_associated_with","statement":"Hypochloremia was associated with poor diuretic response in the heart-failure cohort.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"78229efe-0e30-5b67-a693-0b280cede261","mechanism_event_label":"A low blood measurement identified a pattern, without proving what caused it.","subject":{"id":"47e28f55-b42f-5862-aadf-40e1513680df","slug":"plasma-chloride-concentration","display_name":"Plasma or serum chloride concentration","entity_type_key":"cellular_process"},"object":{"id":"c3172b1b-4ea1-5919-a707-80602377fdb4","slug":"diuretic-response","display_name":"Renal response to loop diuretics","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"78229efe-0e30-5b67-a693-0b280cede261","stable_key":"4df6a932-097e-563a-91fe-5dceec471ffd:chloride-heart-marker-event","event_type":"observed_intervention","label":"A low blood measurement identified a pattern, without proving what caused it.","description":"Hypochloremia was associated with poor diuretic response in the heart-failure cohort.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"47e28f55-b42f-5862-aadf-40e1513680df","slug":"plasma-chloride-concentration","display_name":"Plasma or serum chloride concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c3172b1b-4ea1-5919-a707-80602377fdb4","slug":"diuretic-response","display_name":"Renal response to loop diuretics","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chloride-research/27507113.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"978879bf8054ce7c99ef939133966e618cc8030cb7bd624e250ce32002455927\", \"start_char\": 0, \"end_char\": 2050, \"text_sha256\": \"978879bf8054ce7c99ef939133966e618cc8030cb7bd624e250ce32002455927\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Observational cohort and separate uncontrolled pilot","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"162-person cohort; ten-person pilot, lysine chloride 115 mmol/day for three days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association does not establish causality; the small pilot did not prove clinical benefit or survival improvement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chloride research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chloride","display_name":"Chloride","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human heart failure patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A low blood measurement identified a pattern, without proving what caused it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chloride-p27507113] Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights. (2016). https://pubmed.ncbi.nlm.nih.gov/27507113/ DOI: 10.1161/circheartfailure.116.003180","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and renal diuretic response","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"10ce70b9-b202-5485-be8f-a7c197fa15c5","evidence_kind":"source_excerpt","locator":"Lines 939-950","start_line":939,"end_line":950,"excerpt":"### chloride-heart-marker\nHypochloremia was associated with poor diuretic response in the heart-failure cohort.\nCondition category: biomarker_context\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A low blood measurement identified a pattern, without proving what caused it.\norganism: Human heart failure patients\ntissue_or_cell_type: Blood and renal diuretic response\nexperimental_model: Observational cohort and separate uncontrolled pilot\nlimitations: Association does not establish causality; the small pilot did not prove clinical benefit or survival improvement.\nexposure: 162-person cohort; ten-person pilot, lysine chloride 115 mmol/day for three days\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/27507113.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"978879bf8054ce7c99ef939133966e618cc8030cb7bd624e250ce32002455927\", \"start_char\": 0, \"end_char\": 2050, \"text_sha256\": \"978879bf8054ce7c99ef939133966e618cc8030cb7bd624e250ce32002455927\"}\n[chloride-p27507113] Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights. (2016). https://pubmed.ncbi.nlm.nih.gov/27507113/ DOI: 10.1161/circheartfailure.116.003180","model_system":"Observational cohort and separate uncontrolled pilot","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chloride-p27507113] Hypochloremia and Diuretic Resistance in Heart Failure: Mechanistic Insights. (2016). https://pubmed.ncbi.nlm.nih.gov/27507113/ DOI: 10.1161/circheartfailure.116.003180","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1c2070d5-9f15-5945-b325-d0b49a32c04b","stable_key":"import-4df6a932-097e-563a-91fe-5dceec471ffd","title":"Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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