{"id":"15ce5765-0f6c-5113-abcb-34b6cfce622a","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:reinforcement","predicate":"context_dependent_observation","statement":"Six-volunteer self-administration experiments found modafinil reinforcing under a performance condition but not a relaxation condition.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"27a81e7b-fcbb-53ab-9e8d-edf5bd161d80","mechanism_event_label":"Six-volunteer self-administration experiments found modafinil reinforcing under a performance condition but not a relaxation condition.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"cad5656c-7261-5511-a9b6-cd2b26b1f7f2","slug":"human-modafinil-task-reinforcement","display_name":"Human task-dependent modafinil reinforcement","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"27a81e7b-fcbb-53ab-9e8d-edf5bd161d80","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:reinforcement-event","event_type":"experimental_observation","label":"Six-volunteer self-administration experiments found modafinil reinforcing under a performance condition but not a relaxation condition.","description":"Modafinil's effects can be reinforcing. In six healthy volunteers, a laboratory self-administration procedure found reinforcing effects under a performance condition but not a relaxation condition. This supports task-dependent reinforcement; it neither quantifies population addiction risk nor equates modafinil with cocaine. [Human reinforcement experiment](https://pubmed.ncbi.nlm.nih.gov/15986191/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Modafinil in performance versus relaxation tasks","sequence_order":0,"notes":""},{"entity":{"id":"cad5656c-7261-5511-a9b6-cd2b26b1f7f2","slug":"human-modafinil-task-reinforcement","display_name":"Human task-dependent modafinil reinforcement","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"mixed","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract checked; full methods and figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Modafinil in performance versus relaxation tasks\", \"comparator\": \"Placebo/comparison choice\", \"endpoint\": \"Six-volunteer self-administration experiments found modafinil reinforcing under a performance condition but not a relaxation condition.\", \"effect_direction\": \"mixed\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Human laboratory self-administration, six volunteers; no population addiction-risk estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. 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In six healthy volunteers, a laboratory self-administration procedure found reinforcing effects under a performance condition but not a relaxation condition. This supports task-dependent reinforcement; it neither quantifies population addiction risk nor equates modafinil with cocaine. [Human reinforcement experiment](https://pubmed.ncbi.nlm.nih.gov/15986191/)","model_system":"Human laboratory self-administration, six volunteers; no population addiction-risk estimate.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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