{"id":"15cddb7a-9701-5021-a90d-4438aecfca06","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-human-hdl-carriage","predicate":"carry","statement":"After the high-xanthophyll diet, HDL carried 52% of measured plasma lutein; LDL carried approximately 22%.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"48dfd973-da9b-5d64-bc0b-5b8cddbaff6e","mechanism_event_label":"Lutein traveled in more than one lipoprotein class.","subject":{"id":"5777d3b5-1e4a-5a21-a6c4-0a3c2754a8b6","slug":"hdl-particles","display_name":"High-density lipoprotein particles; preparation specified","entity_type_key":"chemical_species"},"object":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"48dfd973-da9b-5d64-bc0b-5b8cddbaff6e","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-human-hdl-carriage-event","event_type":"observed_intervention","label":"Lutein traveled in more than one lipoprotein class.","description":"After the high-xanthophyll diet, HDL carried 52% of measured plasma lutein; LDL carried approximately 22%.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5777d3b5-1e4a-5a21-a6c4-0a3c2754a8b6","slug":"hdl-particles","display_name":"High-density lipoprotein particles; preparation specified","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/17344498.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"582744e7beef9ad8341bf862c9d344c1f188e6087676bcaa4c32679547fffe79\", \"start_char\": 0, \"end_char\": 1666, \"text_sha256\": \"582744e7beef9ad8341bf862c9d344c1f188e6087676bcaa4c32679547fffe79\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled low- then high-xanthophyll diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"About 1.1 mg/day L+Z for two weeks then 11 mg/day for four weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small dietary study; circulating distribution is not retinal delivery or an intervention to raise HDL cholesterol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Seven AMD patients and five controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Lutein traveled in more than one lipoprotein class.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p17344498] Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration. 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