{"id":"15c5312a-7102-5bf2-a9dc-5206faa57fc1","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-acute-sensitivity-null","predicate":"does_not_change_tested","statement":"In 48 self-described sensitive and 48 matched nonsensitive participants, rated symptoms did not differ between 100 mg aspartame and control bars.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"2a9e6bb7-0e03-5635-bc7c-aca8fedfc830","mechanism_event_label":"A low-dose acute controlled challenge did not reproduce reported sensitivity.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"3a70e351-7504-5ede-a221-28301de4ca5f","slug":"human-aspartame-snackbar-symptoms","display_name":"Human symptoms after 100 mg aspartame snack-bar challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2a9e6bb7-0e03-5635-bc7c-aca8fedfc830","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-acute-sensitivity-null-event","event_type":"observed_relationship","label":"A low-dose acute controlled challenge did not reproduce reported sensitivity.","description":"In 48 self-described sensitive and 48 matched nonsensitive participants, rated symptoms did not differ between 100 mg aspartame and control bars.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3a70e351-7504-5ede-a221-28301de4ca5f","slug":"human-aspartame-snackbar-symptoms","display_name":"Human symptoms after 100 mg aspartame snack-bar challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text and author-list correction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Blinded randomized crossover; sessions at least seven days apart.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a test of all doses, repeated exposure or every vulnerable subgroup. Correction record: Publisher correction concerns author order, affiliations and citation; no experimental-result correction is stated. Correction PMID 25951455 inspected in full text. https://doi.org/10.1371/journal.pone.0126039","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A low-dose acute controlled challenge did not reproduce reported sensitivity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Aspartame sensitivity? 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Correction PMID 25951455 inspected in full text. https://doi.org/10.1371/journal.pone.0126039\nEvidence access: Primary full text and author-list correction\nAspartame sensitivity? A double blind randomised crossover study. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25786106/ · DOI 10.1371/journal.pone.0116212","model_system":"Blinded randomized crossover; sessions at least seven days apart.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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