{"id":"15b99925-eb84-50fc-92a7-ea4fe518f5cb","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-bpnt1-loss-pap","predicate":"loss_accumulates","statement":"Bpnt1 knockout raised mouse liver PAP up to about 50-fold.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3099ca12-3e01-50da-91fa-2287ba0f2629","mechanism_event_label":"Loss of clearance lets the by-product build up.","subject":{"id":"a3f5210f-b74d-5335-ad89-d4b5d33dbd45","slug":"mouse-bpnt1","display_name":"Mouse bisphosphate nucleotidase 1 / Bpnt1","entity_type_key":"protein"},"object":{"id":"c056d2b3-6cf8-500a-a641-1f19dd82cfd4","slug":"pap","display_name":"3-prime-Phosphoadenosine-5-prime-phosphate / PAP","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"3099ca12-3e01-50da-91fa-2287ba0f2629","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-bpnt1-loss-pap-event","event_type":"observed_relationship","label":"Loss of clearance lets the by-product build up.","description":"Bpnt1 knockout raised mouse liver PAP up to about 50-fold.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a3f5210f-b74d-5335-ad89-d4b5d33dbd45","slug":"mouse-bpnt1","display_name":"Mouse bisphosphate nucleotidase 1 / Bpnt1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c056d2b3-6cf8-500a-a641-1f19dd82cfd4","slug":"pap","display_name":"3-prime-Phosphoadenosine-5-prime-phosphate / PAP","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Constitutive Bpnt1 knockout mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genetic absence is not equivalent to dietary lithium exposure or partial drug inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Loss of clearance lets the by-product build up.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23479625/ · DOI 10.1073/pnas.1205001110","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"301bb06c-4f47-5c64-a440-5fb4cf55d2ca","evidence_kind":"source_excerpt","locator":"Lines 128-134","start_line":128,"end_line":134,"excerpt":"## lithium-bpnt1-loss-pap\nLoss of clearance lets the by-product build up.\nBpnt1 knockout raised mouse liver PAP up to about 50-fold.\nModel: Constitutive Bpnt1 knockout mice.\nLimitations: Genetic absence is not equivalent to dietary lithium exposure or partial drug inhibition.\nEvidence access: Primary abstract\nRole for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23479625/ · DOI 10.1073/pnas.1205001110","model_system":"Constitutive Bpnt1 knockout mice.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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