{"id":"153929f5-d2bc-5909-abfa-768138062339","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:sensory-mouse-trpa1","predicate":"increases_in_recorded_experiment","statement":"Allicin engaged the mouse-trpa1-dependent sensory response in mouse channel-loss and neuronal experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1e3fccc8-f56c-5460-8de1-f58f17bb0e63","mechanism_event_label":"Allicin engaged the mouse-trpa1-dependent sensory response in mouse channel-loss and neuronal experiments.","subject":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"object":{"id":"05575212-6bc2-544a-8983-16b578525891","slug":"mouse-trpa1","display_name":"Mouse Trpa1 ion channel","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"1e3fccc8-f56c-5460-8de1-f58f17bb0e63","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:sensory-mouse-trpa1-event","event_type":"biochemical_relationship","label":"Allicin engaged the mouse-trpa1-dependent sensory response in mouse channel-loss and neuronal experiments.","description":"**Sensory activation.** Experiments identified allicin-dependent activation of TRPA1 and TRPV1. In the later mouse study, allicin stimulated dorsal-root-ganglion neurons and pain-related behavior. Removing either Trpa1 or Trpv1 reduced, but did not abolish, the behavioral response. The channels provide overlapping sensory routes rather than one exclusive receptor. Irritation, chemical burns, and allergic dermatitis are different outcomes. [Macpherson 2005](https://pubmed.ncbi.nlm.nih.gov/15916949/) [Salazar 2008](https://pmc.ncbi.nlm.nih.gov/articles/PMC4370189/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"05575212-6bc2-544a-8983-16b578525891","slug":"mouse-trpa1","display_name":"Mouse Trpa1 ion channel","entity_type_key":"protein"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""},{"entity":{"id":"53f6d920-ef79-5664-b068-71e16e0d2985","slug":"mouse-allicin-sensory-excitation","display_name":"Mouse sensory-neuron excitation by allicin","entity_type_key":"cellular_process"},"role":"recorded cellular response","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse DRG neurons and pain-related behavior; separate single-channel knockout comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Participation supported by converging comparisons; the other channel still contributes. 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In the later mouse study, allicin stimulated dorsal-root-ganglion neurons and pain-related behavior. Removing either Trpa1 or Trpv1 reduced, but did not abolish, the behavioral response. The channels provide overlapping sensory routes rather than one exclusive receptor. Irritation, chemical burns, and allergic dermatitis are different outcomes. [Macpherson 2005](https://pubmed.ncbi.nlm.nih.gov/15916949/) [Salazar 2008](https://pmc.ncbi.nlm.nih.gov/articles/PMC4370189/)","model_system":"Mouse DRG neurons and pain-related behavior; separate single-channel knockout comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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