{"id":"1536a54b-3e77-5338-92bb-9907e9606220","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-dxa-device-dependence","predicate":"alters_xray_attenuation","statement":"Theoretical attenuation calculations predicted strontium overestimation factors around 9–10.8 for the tested DXA systems, with different factors for single-energy CT.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"028cb59a-d24a-5e86-a6a0-96d4d843f446","mechanism_event_label":"The size of the measurement effect depends partly on the method.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"fad5f24f-9f91-52bc-aac6-c3a1bac8c5f6","slug":"strontium-dxa-overestimation","display_name":"Strontium-associated DXA bone-density overestimation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"028cb59a-d24a-5e86-a6a0-96d4d843f446","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-dxa-device-dependence-event","event_type":"observed_relationship","label":"The size of the measurement effect depends partly on the method.","description":"Theoretical attenuation calculations predicted strontium overestimation factors around 9–10.8 for the tested DXA systems, with different factors for single-energy CT.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fad5f24f-9f91-52bc-aac6-c3a1bac8c5f6","slug":"strontium-dxa-overestimation","display_name":"Strontium-associated DXA bone-density overestimation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Physical modeling using X-ray attenuation coefficients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Historical device calculations, not universal current scanner calibration; bone retention also matters after treatment stops.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The size of the measurement effect depends partly on the method.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of bone strontium on BMD measurements. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17289524/ · DOI 10.1016/j.jocd.2006.10.004","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"3ea36353-c1cb-5072-a7cd-ae9b83c5fd37","evidence_kind":"source_excerpt","locator":"Lines 318-324","start_line":318,"end_line":324,"excerpt":"## strontium-dxa-device-dependence\nThe size of the measurement effect depends partly on the method.\nTheoretical attenuation calculations predicted strontium overestimation factors around 9–10.8 for the tested DXA systems, with different factors for single-energy CT.\nModel: Physical modeling using X-ray attenuation coefficients.\nLimitations: Historical device calculations, not universal current scanner calibration; bone retention also matters after treatment stops.\nEvidence access: Primary abstract\nEffect of bone strontium on BMD measurements. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17289524/ · DOI 10.1016/j.jocd.2006.10.004","model_system":"Physical modeling using X-ray attenuation coefficients.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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