{"id":"1515f047-ac38-5edc-b844-4a90c5549a39","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-fmo1-reducing-cofactors","predicate":"supports","statement":"Human FMO1 converted hypotaurine to taurine with either NADPH or NADH as the reducing cofactor in the reported assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7bf4ef37-d7dc-55eb-9961-91ad5b6ff7cb","mechanism_event_label":"Niacin-derived electron carriers support this synthetic reaction.","subject":{"id":"4aba2a5e-8d06-5304-bb01-c0402b225a94","slug":"nadph","display_name":"NADPH","entity_type_key":"small_molecule"},"object":{"id":"202fbc6d-afd3-54b2-9193-1f6e06d48d3d","slug":"fmo1","display_name":"Human flavin-containing monooxygenase 1 / FMO1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"7bf4ef37-d7dc-55eb-9961-91ad5b6ff7cb","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-fmo1-reducing-cofactors-event","event_type":"observed_relationship","label":"Niacin-derived electron carriers support this synthetic reaction.","description":"Human FMO1 converted hypotaurine to taurine with either NADPH or NADH as the reducing cofactor in the reported assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4aba2a5e-8d06-5304-bb01-c0402b225a94","slug":"nadph","display_name":"NADPH","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"202fbc6d-afd3-54b2-9193-1f6e06d48d3d","slug":"fmo1","display_name":"Human flavin-containing monooxygenase 1 / FMO1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9fbf2e03-16a9-5ca7-965c-0bfc07ca24da","slug":"nadh","display_name":"NADH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"eeff5174-9aa8-5f34-b107-e826edde648c","slug":"hypotaurine","display_name":"Hypotaurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human FMO1 biochemistry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"NAD(P)H availability, FMO1 abundance and substrate availability are separate variables; no niacin repletion effect was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Niacin-derived electron carriers support this synthetic reaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32156684/ · DOI 10.1124/dmd.119.089995","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"374c01b1-998b-5e42-988b-84c4e0aff221","evidence_kind":"source_excerpt","locator":"Lines 81-87","start_line":81,"end_line":87,"excerpt":"## taurine-fmo1-reducing-cofactors\nNiacin-derived electron carriers support this synthetic reaction.\nHuman FMO1 converted hypotaurine to taurine with either NADPH or NADH as the reducing cofactor in the reported assays.\nModel: Recombinant human FMO1 biochemistry.\nLimitations: NAD(P)H availability, FMO1 abundance and substrate availability are separate variables; no niacin repletion effect was tested.\nEvidence access: Primary abstract\nFlavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32156684/ · DOI 10.1124/dmd.119.089995","model_system":"Recombinant human FMO1 biochemistry.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}