{"id":"14ccb635-bf23-5165-8d94-9ba1d7e50c5b","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-polyamine-rescue","predicate":"part_of_rescue_for","statement":"Agmatine lowered intracellular polyamines and suppressed transformed-cell proliferation; polyamine supplementation reversed growth suppression.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3bae2d2c-55a4-5e7c-b85a-e08964d354aa","mechanism_event_label":"Restoring a downstream pool changed the cellular outcome.","subject":{"id":"c70b0aa7-ee82-5949-b094-51f98d327b03","slug":"polyamine-supplement-mixture-1998","display_name":"Polyamine supplementation pool in the 1998 agmatine experiments","entity_type_key":"small_molecule"},"object":{"id":"0d3d6681-115e-5ad2-8b66-5598a8bc5094","slug":"transformed-cell-agmatine-growth-suppression","display_name":"Agmatine-associated growth suppression in the 1998 transformed-cell model","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3bae2d2c-55a4-5e7c-b85a-e08964d354aa","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-polyamine-rescue-event","event_type":"observed_relationship","label":"Restoring a downstream pool changed the cellular outcome.","description":"Agmatine lowered intracellular polyamines and suppressed transformed-cell proliferation; 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polyamine supplementation reversed growth suppression.\nModel: Transformed-cell supplementation experiment.\nLimitations: The accessed abstract reports polyamine supplementation as a group, not a spermidine-only rescue or cancer therapy.\nEvidence access: Primary abstract\nAgmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9624108/ · DOI 10.1074/jbc.273.25.15313","model_system":"Transformed-cell supplementation experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e0426971-7d13-51c9-8354-6547b664f1cf","stable_key":"import-220adaab-10d8-5c4e-a3f5-a48700ea794d","title":"Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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