{"id":"14aa1a79-b5b4-59bb-89eb-5aecd9131d5d","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-oil-cyp2c9","predicate":"inhibits","statement":"The C. verum oil inhibited CYP2C9 catalytic activity in the study assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bb0eb7aa-4288-550e-8dd2-e5b3479c18fc","mechanism_event_label":"This separate mixture result remains distinct from the pure chemical result.","subject":{"id":"3b21d651-c1e3-5427-b568-91b16e7c3263","slug":"ceylon-oil-2025","display_name":"C. verum oil preparation in the 2025 metabolic clearance study","entity_type_key":"chemical_species"},"object":{"id":"c96f78f4-5bca-5867-9ac1-652891d40aa0","slug":"cyp2c9","display_name":"Human cytochrome P450 2C9","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"bb0eb7aa-4288-550e-8dd2-e5b3479c18fc","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-oil-cyp2c9-event","event_type":"biochemical_relationship","label":"This separate mixture result remains distinct from the pure chemical result.","description":"The C. verum oil inhibited CYP2C9 catalytic activity in the study assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3b21d651-c1e3-5427-b568-91b16e7c3263","slug":"ceylon-oil-2025","display_name":"C. verum oil preparation in the 2025 metabolic clearance study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c96f78f4-5bca-5867-9ac1-652891d40aa0","slug":"cyp2c9","display_name":"Human cytochrome P450 2C9","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/39845339.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"243c3bd561d9ff4d7dfe10fa748b1aacc0941a4ec9f712615f7dd7df4e98f118\", \"start_char\": 0, \"end_char\": 1463, \"text_sha256\": \"243c3bd561d9ff4d7dfe10fa748b1aacc0941a4ec9f712615f7dd7df4e98f118\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human receptor reporters and CYP inhibition assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oil/parent/metabolite comparisons; PXR 0.62–20 micrograms/mL for 24 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reporter activation is not demonstrated induction of clinical drug clearance. HepG2 is liver-derived; full results distinguish it from intestinal LS174T.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human-derived reporter cells and human CYP assay systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This separate mixture result remains distinct from the pure chemical result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p39845339] Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde. (2025). https://pubmed.ncbi.nlm.nih.gov/39845339/ DOI: 10.1016/j.fochms.2024.100237","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"HepG2, LS174T and AhR reporter cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"75a871b3-2ed3-5be5-b4da-09b2ba7e5bec","evidence_kind":"source_excerpt","locator":"Lines 896-907","start_line":896,"end_line":907,"excerpt":"### ceylon-oil-cyp2c9\nThe C. verum oil inhibited CYP2C9 catalytic activity in the study assay.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This separate mixture result remains distinct from the pure chemical result.\norganism: Human-derived reporter cells and human CYP assay systems\ntissue_or_cell_type: HepG2, LS174T and AhR reporter cells\nexperimental_model: Human receptor reporters and CYP inhibition assays\nlimitations: Reporter activation is not demonstrated induction of clinical drug clearance. HepG2 is liver-derived; full results distinguish it from intestinal LS174T.\nexposure: Oil/parent/metabolite comparisons; PXR 0.62–20 micrograms/mL for 24 hours\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/39845339.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"243c3bd561d9ff4d7dfe10fa748b1aacc0941a4ec9f712615f7dd7df4e98f118\", \"start_char\": 0, \"end_char\": 1463, \"text_sha256\": \"243c3bd561d9ff4d7dfe10fa748b1aacc0941a4ec9f712615f7dd7df4e98f118\"}\n[ceylon-p39845339] Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde. (2025). https://pubmed.ncbi.nlm.nih.gov/39845339/ DOI: 10.1016/j.fochms.2024.100237","model_system":"Human receptor reporters and CYP inhibition assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ceylon-p39845339] Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde. (2025). https://pubmed.ncbi.nlm.nih.gov/39845339/ DOI: 10.1016/j.fochms.2024.100237","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3aed3c5b-8016-5e37-ad6f-9019d34d19eb","stable_key":"import-3d41d18a-e13a-59a0-a081-55bfcdd43e55","title":"Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"639b1d8dcff42f2cf1f00a7dc38202289b70213e37c357c375b1f5905d6cf832","revision_id":"9675eb03-ee34-5160-b928-46b6ca9d1ecc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}