{"id":"14a223c5-6bf9-5430-9408-6d63dd204e32","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-sheep-insulin","predicate":"reduces_tested","statement":"Both D-aspartate infusion doses reduced plasma insulin; glucose and circulating catecholamines did not significantly change.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"77ef145f-8c57-58b2-9e53-252272043e5e","mechanism_event_label":"Hormone concentrations changed without a demonstrated glucose improvement.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"05dadb72-203a-5095-af88-6ac091451225","slug":"sheep-plasma-insulin","display_name":"Plasma insulin in wethers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"77ef145f-8c57-58b2-9e53-252272043e5e","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-sheep-insulin-event","event_type":"observed_relationship","label":"Hormone concentrations changed without a demonstrated glucose improvement.","description":"Both D-aspartate infusion doses reduced plasma insulin; glucose and circulating catecholamines did not significantly change.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"05dadb72-203a-5095-af88-6ac091451225","slug":"sheep-plasma-insulin","display_name":"Plasma insulin in wethers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Wethers; 20-minute intravenous infusion at 0.05 or 0.1 mmol/kg/min.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not establish improved insulin sensitivity or a desirable human metabolic outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Hormone concentrations changed without a demonstrated glucose improvement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"D-aspartate stimulates growth hormone secretion in wethers. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39432441/ · DOI 10.1093/jas/skae318","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"73023208-e80c-5f7a-9795-efaca2a343e8","evidence_kind":"source_excerpt","locator":"Lines 424-430","start_line":424,"end_line":430,"excerpt":"## d-aspartate-sheep-insulin\nHormone concentrations changed without a demonstrated glucose improvement.\nBoth D-aspartate infusion doses reduced plasma insulin; glucose and circulating catecholamines did not significantly change.\nModel: Wethers; 20-minute intravenous infusion at 0.05 or 0.1 mmol/kg/min.\nLimitations: This does not establish improved insulin sensitivity or a desirable human metabolic outcome.\nEvidence access: Primary abstract\nD-aspartate stimulates growth hormone secretion in wethers. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39432441/ · DOI 10.1093/jas/skae318","model_system":"Wethers; 20-minute intravenous infusion at 0.05 or 0.1 mmol/kg/min.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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