{"id":"1446c54e-344a-5b28-9197-9080869f2518","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-dyrk","predicate":"inhibits","statement":"The kinase panel reported EGCG inhibition with IC50 0.33 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2e26c09c-0980-56d3-85ac-cca423b02af6","mechanism_event_label":"A kinase-panel experiment identified another target.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"2569bcb0-64ed-5414-9bf9-306a75488f85","slug":"dyrk1a-family","display_name":"Dual-specificity tyrosine-phosphorylation regulated kinase 1A family","entity_type_key":"protein_family"},"evidence_count":1,"mechanism_event":{"id":"2e26c09c-0980-56d3-85ac-cca423b02af6","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-dyrk-event","event_type":"observed_relationship","label":"A kinase-panel experiment identified another target.","description":"The kinase panel reported EGCG inhibition with IC50 0.33 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2569bcb0-64ed-5414-9bf9-306a75488f85","slug":"dyrk1a-family","display_name":"Dual-specificity tyrosine-phosphorylation regulated kinase 1A family","entity_type_key":"protein_family"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Panel of 28 protein kinases.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Two inhibited kinases in this panel do not establish selectivity across the entire kinome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A kinase-panel experiment identified another target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The specificities of protein kinase inhibitors: an update. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12534346/ · DOI 10.1042/bj20021535","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5c84479b-2901-5182-9541-1dc5e756ed7c","evidence_kind":"source_excerpt","locator":"Lines 236-242","start_line":236,"end_line":242,"excerpt":"## egcg-dyrk\nA kinase-panel experiment identified another target.\nThe kinase panel reported EGCG inhibition with IC50 0.33 micromolar.\nModel: Panel of 28 protein kinases.\nLimitations: Two inhibited kinases in this panel do not establish selectivity across the entire kinome.\nEvidence access: primary abstract.\nThe specificities of protein kinase inhibitors: an update. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12534346/ · DOI 10.1042/bj20021535","model_system":"Panel of 28 protein kinases.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}