{"id":"14347350-8311-57bd-ae1c-a7efb1cd181a","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-microbial-rescue","predicate":"enables_escape_from","statement":"Removing bacterial PncA abolished, and supplying it enabled, bacterial protection against NAMPT inhibitors in the tested cancer-cell and xenograft systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"51e6eda7-befb-5e7d-94f7-13e051fdd1f6","mechanism_event_label":"An alternative precursor source can defeat a blockade of salvage.","subject":{"id":"7944df5f-b616-55c0-8563-edf3943dbf7d","slug":"escherichia-coli-pnca","display_name":"Escherichia coli nicotinamidase PncA","entity_type_key":"protein"},"object":{"id":"f24650eb-522d-5f7b-9f67-ea757b473061","slug":"nampt-inhibitor-cell-killing","display_name":"NAMPT-inhibitor-induced cancer-cell killing","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"51e6eda7-befb-5e7d-94f7-13e051fdd1f6","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-microbial-rescue-event","event_type":"observed_relationship","label":"An alternative precursor source can defeat a blockade of salvage.","description":"Removing bacterial PncA abolished, and supplying it enabled, bacterial protection against NAMPT inhibitors in the tested cancer-cell and xenograft systems.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7944df5f-b616-55c0-8563-edf3943dbf7d","slug":"escherichia-coli-pnca","display_name":"Escherichia coli nicotinamidase PncA","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f24650eb-522d-5f7b-9f67-ea757b473061","slug":"nampt-inhibitor-cell-killing","display_name":"NAMPT-inhibitor-induced cancer-cell killing","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8272125c-0d87-5920-9dae-7409b797bbfa","slug":"nampt","display_name":"Human nicotinamide phosphoribosyltransferase / NAMPT","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"ee8024b9-b9e9-513f-9bcd-b3d30e1990ba","slug":"naprt","display_name":"Human nicotinate phosphoribosyltransferase / NAPRT","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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