{"id":"14342676-896e-594b-bfb0-e9bf8e993db9","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-caffeine-jitteriness-null","predicate":"did_not_significantly_reduce_caffeine_effect_on","statement":"Theanine did not significantly reduce caffeine-associated jitteriness in the same experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ebc0bac1-ec74-5b87-be03-9ac3137c3f3a","mechanism_event_label":"The blood-pressure result cannot be generalized to every subjective effect.","subject":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"object":{"id":"9fa7c474-3113-574c-9563-63c965e39192","slug":"subjective-jitteriness","display_name":"Subjective jitteriness","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ebc0bac1-ec74-5b87-be03-9ac3137c3f3a","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-caffeine-jitteriness-null-event","event_type":"observed_intervention","label":"The blood-pressure result cannot be generalized to every subjective effect.","description":"Theanine did not significantly reduce caffeine-associated jitteriness in the same experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"coexposure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9fa7c474-3113-574c-9563-63c965e39192","slug":"subjective-jitteriness","display_name":"Subjective jitteriness","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/17891480.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"dcd12cbd6fb30feee591192380733184f9928be3c146e39a4debc121a05b8815\", \"start_char\": 0, \"end_char\": 1581, \"text_sha256\": \"dcd12cbd6fb30feee591192380733184f9928be3c146e39a4debc121a05b8815\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind caffeine interaction experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"250 mg caffeine with or without 200 mg theanine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute caffeine exposure; no basis for treating chronic hypertension or assuming caffeine adverse effects are all prevented.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"48 healthy humans","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The blood-pressure result cannot be generalized to every subjective effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p17891480] Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together. 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