{"id":"1431f982-4464-531b-a7ca-d7937ec5e48d","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-rosemary-iron","predicate":"decreases_in_recorded_comparison","statement":"Rosemary phenolic-rich extract added to a meal reduced nonheme-iron absorption in women.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a709e507-d4dd-5b96-90ad-c19f7899fc85","mechanism_event_label":"Rosemary phenolic-rich extract added to a meal reduced nonheme-iron absorption in women.","subject":{"id":"494ad35b-f873-5d10-920e-9de804111e84","slug":"rosemary-phenolic-extract","display_name":"Rosemary phenolic-rich extract","entity_type_key":"botanical"},"object":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a709e507-d4dd-5b96-90ad-c19f7899fc85","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-rosemary-iron-event","event_type":"experimental_observation","label":"Rosemary phenolic-rich extract added to a meal reduced nonheme-iron absorption in women.","description":"### ra-rosemary-iron\n\nRosemary phenolic-rich extract added to a meal reduced nonheme-iron absorption in women.\nExtract-level outcome. Isolated RA contribution and clinical iron-deficiency incidence were not established.\nModel and exposure: 14 women, ages 19–39; radiolabeled meals in ABBA/BAAB design.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Green tea or rosemary extract added to foods reduces nonheme-iron absorption. | 2001 | https://pubmed.ncbi.nlm.nih.gov/11237939/ | https://doi.org/10.1093/ajcn/73.3.607 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"494ad35b-f873-5d10-920e-9de804111e84","slug":"rosemary-phenolic-extract","display_name":"Rosemary phenolic-rich extract","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"Meal with rosemary extract","sequence_order":0,"notes":""},{"entity":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"measured dietary element","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"possible constituent, not assigned causal responsibility","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Meal with rosemary extract\", \"comparator\": \"Identical meal without extract\", \"endpoint\": \"Rosemary phenolic-rich extract added to a meal reduced nonheme-iron absorption in women.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"14 women, ages 19–39; radiolabeled meals in ABBA/BAAB design.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Rosemary phenolic-rich extract added to a meal reduced nonheme-iron absorption in women.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Green tea or rosemary extract added to foods reduces nonheme-iron absorption. | https://pubmed.ncbi.nlm.nih.gov/11237939/ | https://doi.org/10.1093/ajcn/73.3.607","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-rosemary-iron; Extract-level outcome. Isolated RA contribution and clinical iron-deficiency incidence were not established.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b28cea41-f11b-5abc-b928-1e15519f5f9f","evidence_kind":"source_excerpt","locator":"Lines 353-359","start_line":353,"end_line":359,"excerpt":"### ra-rosemary-iron\n\nRosemary phenolic-rich extract added to a meal reduced nonheme-iron absorption in women.\nExtract-level outcome. Isolated RA contribution and clinical iron-deficiency incidence were not established.\nModel and exposure: 14 women, ages 19–39; radiolabeled meals in ABBA/BAAB design.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Green tea or rosemary extract added to foods reduces nonheme-iron absorption. | 2001 | https://pubmed.ncbi.nlm.nih.gov/11237939/ | https://doi.org/10.1093/ajcn/73.3.607 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"14 women, ages 19–39; radiolabeled meals in ABBA/BAAB design.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}