{"id":"1423bef5-e52a-54cf-aafd-db2975a3d119","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-bone-localization","predicate":"results_in","statement":"Biopsies from ranelate-treated osteoporotic women localized strontium mainly to bone structural units formed during treatment, with old units reported devoid of strontium in the analyzed samples.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2343bdfd-4c73-5d3b-8264-5bdaf872cb44","mechanism_event_label":"Bone turnover determines where the element is incorporated.","subject":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"object":{"id":"d669dba0-d2a7-54ba-9641-542db7948422","slug":"human-new-bone-strontium-deposition","display_name":"Strontium deposition in newly formed human bone","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2343bdfd-4c73-5d3b-8264-5bdaf872cb44","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-bone-localization-event","event_type":"observed_relationship","label":"Bone turnover determines where the element is incorporated.","description":"Biopsies from ranelate-treated osteoporotic women localized strontium mainly to bone structural units formed during treatment, with old units reported devoid of strontium in the analyzed samples.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d669dba0-d2a7-54ba-9641-542db7948422","slug":"human-new-bone-strontium-deposition","display_name":"Strontium deposition in newly formed human bone","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human treatment biopsies; X-ray microanalysis and cartography, up to three years for these analyses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Sampled iliac bone does not define uptake or release kinetics for the entire skeleton.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Bone turnover determines where the element is incorporated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. · 2010 · https://pubmed.ncbi.nlm.nih.gov/19597910/ · DOI 10.1007/s00198-009-1005-z","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"536b04b9-b488-55ed-af8c-7b5f32096a23","evidence_kind":"source_excerpt","locator":"Lines 294-300","start_line":294,"end_line":300,"excerpt":"## strontium-bone-localization\nBone turnover determines where the element is incorporated.\nBiopsies from ranelate-treated osteoporotic women localized strontium mainly to bone structural units formed during treatment, with old units reported devoid of strontium in the analyzed samples.\nModel: Human treatment biopsies; X-ray microanalysis and cartography, up to three years for these analyses.\nLimitations: Sampled iliac bone does not define uptake or release kinetics for the entire skeleton.\nEvidence access: Primary abstract\nIn osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. · 2010 · https://pubmed.ncbi.nlm.nih.gov/19597910/ · DOI 10.1007/s00198-009-1005-z","model_system":"Human treatment biopsies; X-ray microanalysis and cartography, up to three years for these analyses.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"51221949263cdf8a22a79c32e3989599de1a37dc215700e0a076f436b40a1005","revision_id":"84f6df49-c456-5ad2-8214-cc69d5dc7722","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}