{"id":"13eae892-9e79-55b1-911e-139da9b5b50f","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-ethanol-oxidation-hepatic-plp","predicate":"reduces","statement":"The effect of ethanol oxidation on hepatic pyridoxal 5-phosphate metabolism accompanied the plasma changes seen in chronic alcohol abuse.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"5209334e-5597-5ef7-adc1-c224f152bb4d","mechanism_event_label":"The same loss shows up in the organ that does the oxidising.","subject":{"id":"e653a47d-0723-5479-9572-6ed51aa8d5b0","slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"},"object":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"5209334e-5597-5ef7-adc1-c224f152bb4d","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-ethanol-oxidation-hepatic-plp-event","event_type":"biochemical_relationship","label":"The same loss shows up in the organ that does the oxidising.","description":"The effect of ethanol oxidation on hepatic pyridoxal 5-phosphate metabolism accompanied the plasma changes seen in chronic alcohol abuse.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e653a47d-0723-5479-9572-6ed51aa8d5b0","slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/1168205.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b436a7e8353028a5eb7cf608b2a272b39968ee2af717dbae8fb03a39cb77180d\", \"start_char\": 0, \"end_char\": 1391, \"text_sha256\": \"b436a7e8353028a5eb7cf608b2a272b39968ee2af717dbae8fb03a39cb77180d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Hepatic PLP metabolism during ethanol oxidation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ethanol oxidation with hepatic PLP measurement","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Extends the mechanism to liver. Part of the same series as the erythrocyte work, so the records share a laboratory lineage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human and animal liver","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same loss shows up in the organ that does the oxidising.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p1168205] Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism. (1975). https://pubmed.ncbi.nlm.nih.gov/1168205/ DOI: 10.1172/jci108003","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c61ac3ac-e94d-532f-868c-9f228c4d3d47","evidence_kind":"source_excerpt","locator":"Lines 670-681","start_line":670,"end_line":681,"excerpt":"### alcohol-ethanol-oxidation-hepatic-plp\nThe effect of ethanol oxidation on hepatic pyridoxal 5-phosphate metabolism accompanied the plasma changes seen in chronic alcohol abuse.\nCondition category: nutrient_deficiency\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: The same loss shows up in the organ that does the oxidising.\norganism: Human and animal liver\ntissue_or_cell_type: Liver\nexperimental_model: Hepatic PLP metabolism during ethanol oxidation\nlimitations: Extends the mechanism to liver. Part of the same series as the erythrocyte work, so the records share a laboratory lineage.\nexposure: Ethanol oxidation with hepatic PLP measurement\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/1168205.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b436a7e8353028a5eb7cf608b2a272b39968ee2af717dbae8fb03a39cb77180d\", \"start_char\": 0, \"end_char\": 1391, \"text_sha256\": \"b436a7e8353028a5eb7cf608b2a272b39968ee2af717dbae8fb03a39cb77180d\"}\n[alcohol-p1168205] Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism. (1975). https://pubmed.ncbi.nlm.nih.gov/1168205/ DOI: 10.1172/jci108003","model_system":"Hepatic PLP metabolism during ethanol oxidation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [alcohol-p1168205] Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism. (1975). https://pubmed.ncbi.nlm.nih.gov/1168205/ DOI: 10.1172/jci108003","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4b310db0-1387-548c-9e3d-6d2ed634b2cd","stable_key":"import-fcc4fa9c-4dc8-5566-b780-1a486c4d3e72","title":"Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"cb7e8dc390e8bf302cd5e230cadff6ce9847b4aad8a3691a308964d93ba59a85","revision_id":"4b344e1e-4129-579c-a058-50262b03f9a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}