{"id":"13e3dbec-a3ad-516b-a3a0-1f210ccf527c","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-late-challenge-hormone","predicate":"coincides_with_higher","statement":"Endogenous melatonin was about 3.5-fold higher in the late condition.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cbc044a6-5f5d-5483-b87b-1c268cddd46f","mechanism_event_label":"Late carbohydrate exposure coincided with a stronger night signal.","subject":{"id":"684791f6-7936-5cd4-aac1-8d8a07dae6a7","slug":"late-evening-glucose-challenge","display_name":"Late-evening glucose challenge relative to habitual bedtime","entity_type_key":"cellular_process"},"object":{"id":"13670e9e-26f8-55e6-acd8-55f937e95b9c","slug":"melatonin-circulating-exposure","display_name":"Circulating melatonin exposure, route and timing specified","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cbc044a6-5f5d-5483-b87b-1c268cddd46f","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-late-challenge-hormone-event","event_type":"observed_intervention","label":"Late carbohydrate exposure coincided with a stronger night signal.","description":"Endogenous melatonin was about 3.5-fold higher in the late condition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"endogenous_hormone","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"684791f6-7936-5cd4-aac1-8d8a07dae6a7","slug":"late-evening-glucose-challenge","display_name":"Late-evening glucose challenge relative to habitual bedtime","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"13670e9e-26f8-55e6-acd8-55f937e95b9c","slug":"melatonin-circulating-exposure","display_name":"Circulating melatonin exposure, route and timing specified","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/35015083.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"14878cd566ac009dde6fd0a6cc78adf1a4b48cfb2bc09e262568c909f84f236e\", \"start_char\": 0, \"end_char\": 1688, \"text_sha256\": \"14878cd566ac009dde6fd0a6cc78adf1a4b48cfb2bc09e262568c909f84f236e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized crossover early versus late glucose-challenge study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"75 g OGTT four versus one hour before habitual bedtime after eight-hour fast","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Glucose drinks simulated meal timing. Timing, endogenous melatonin and other circadian factors co-varied; the intervention did not selectively manipulate melatonin alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"845 Spanish adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Late carbohydrate exposure coincided with a stronger night signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p35015083] Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35015083/ DOI: 10.2337/dc21-1314","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Endogenous melatonin and evening glucose handling","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"96b4b1f8-9122-5bb5-9fdd-f31f0b4debea","evidence_kind":"source_excerpt","locator":"Lines 1150-1161","start_line":1150,"end_line":1161,"excerpt":"### melatonin-late-challenge-hormone\nEndogenous melatonin was about 3.5-fold higher in the late condition.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Late carbohydrate exposure coincided with a stronger night signal.\norganism: 845 Spanish adults\ntissue_or_cell_type: Endogenous melatonin and evening glucose handling\nexperimental_model: Randomized crossover early versus late glucose-challenge study\nlimitations: Glucose drinks simulated meal timing. Timing, endogenous melatonin and other circadian factors co-varied; the intervention did not selectively manipulate melatonin alone.\nexposure: 75 g OGTT four versus one hour before habitual bedtime after eight-hour fast\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/35015083.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"14878cd566ac009dde6fd0a6cc78adf1a4b48cfb2bc09e262568c909f84f236e\", \"start_char\": 0, \"end_char\": 1688, \"text_sha256\": \"14878cd566ac009dde6fd0a6cc78adf1a4b48cfb2bc09e262568c909f84f236e\"}\n[melatonin-p35015083] Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. 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