{"id":"13dd5935-c350-5a2c-b4f8-ed7cbcbe643a","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-ms-phase2-walking-null","predicate":"did_not_improve","statement":"The larger phase 2 trial found no improvement in timed walking speed or other reported clinical outcomes at 24 months.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"6056c43d-7a09-5dea-a5b6-fea6ccf861f4","mechanism_event_label":"The later study did not establish functional benefit.","subject":{"id":"ab091982-3acb-5a87-80fb-85dfe292c1e0","slug":"lipoic-acid","display_name":"Lipoic acid","entity_type_key":"small_molecule"},"object":{"id":"7c73f7db-bb09-5cd8-9d28-21c13a0dad31","slug":"progressive-ms-timed-walking-speed","display_name":"Timed walking speed in progressive multiple sclerosis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6056c43d-7a09-5dea-a5b6-fea6ccf861f4","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-ms-phase2-walking-null-event","event_type":"observed_intervention","label":"The later study did not establish functional benefit.","description":"The larger phase 2 trial found no improvement in timed walking speed or other reported clinical outcomes at 24 months.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ab091982-3acb-5a87-80fb-85dfe292c1e0","slug":"lipoic-acid","display_name":"Lipoic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7c73f7db-bb09-5cd8-9d28-21c13a0dad31","slug":"progressive-ms-timed-walking-speed","display_name":"Timed walking speed in progressive multiple sclerosis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ala-research/41397213.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7fbea8d712bb6bea0dd8b7cfde3133b06d70a6eb881917767f4385f61c8d27ba\", \"start_char\": 0, \"end_char\": 3010, \"text_sha256\": \"7fbea8d712bb6bea0dd8b7cfde3133b06d70a6eb881917767f4385f61c8d27ba\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Phase 2 randomized placebo-controlled progressive-MS trial; online December 2025, 2026 issue","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oral ALA 1200 mg/day for 24 months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Primary timed-walking result was null; imaging interpretation complicated by T2 lesion volume and differential discontinuation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lipoic-acid","display_name":"Lipoic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The later study did not establish functional benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ala-p41397213] Lipoic Acid for Treatment of Progressive Multiple Sclerosis: A Phase 2 Randomized Clinical Trial. (2026). https://pubmed.ncbi.nlm.nih.gov/41397213/ DOI: 10.1212/wnl.0000000000214454","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"115 participants, 54 ALA and 61 placebo","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6b5c1fd9-5e91-56f0-b3c2-7029f6d88274","evidence_kind":"source_excerpt","locator":"Lines 1261-1272","start_line":1261,"end_line":1272,"excerpt":"### ala-ms-phase2-walking-null\nThe larger phase 2 trial found no improvement in timed walking speed or other reported clinical outcomes at 24 months.\nCondition category: normal\nnutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The later study did not establish functional benefit.\norganism: Human\ntissue_or_cell_type: 115 participants, 54 ALA and 61 placebo\nexperimental_model: Phase 2 randomized placebo-controlled progressive-MS trial; online December 2025, 2026 issue\nlimitations: Primary timed-walking result was null; imaging interpretation complicated by T2 lesion volume and differential discontinuation.\nexposure: Oral ALA 1200 mg/day for 24 months\nevidence_span: {\"source_cache\": \"artifacts/ala-research/41397213.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7fbea8d712bb6bea0dd8b7cfde3133b06d70a6eb881917767f4385f61c8d27ba\", \"start_char\": 0, \"end_char\": 3010, \"text_sha256\": \"7fbea8d712bb6bea0dd8b7cfde3133b06d70a6eb881917767f4385f61c8d27ba\"}\n[ala-p41397213] Lipoic Acid for Treatment of Progressive Multiple Sclerosis: A Phase 2 Randomized Clinical Trial. 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