{"id":"13a177bb-2d82-54dc-a132-67f605b88f94","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-oleate","predicate":"reduces","statement":"Adding t10,c12 CLA reduced oleic-acid uptake and oxidation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"43db394b-0321-5c95-9751-dd755d0d9c58","mechanism_event_label":"This fat-cell result was not increased fat burning.","subject":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"object":{"id":"faba2c01-c1b7-599d-a4d3-322d3bc02a76","slug":"human-adipocyte-oleate-uptake-oxidation","display_name":"Human adipocyte oleate uptake and oxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"43db394b-0321-5c95-9751-dd755d0d9c58","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-oleate-event","event_type":"observed_relationship","label":"This fat-cell result was not increased fat burning.","description":"Adding t10,c12 CLA reduced oleic-acid uptake and oxidation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"faba2c01-c1b7-599d-a4d3-322d3bc02a76","slug":"human-adipocyte-oleate-uptake-oxidation","display_name":"Human adipocyte oleate uptake and oxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f13c95ee-180b-5ec9-8e74-229cf2acc709","slug":"oleic-acid","display_name":"Oleic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary cultures of differentiating human preadipocytes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not determine whole-body fuel oxidation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"This fat-cell result was not increased fat burning.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12730300/ · DOI 10.1194/jlr.M300001-JLR200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ead3f8a9-e949-562e-8207-3a30cddf0233","evidence_kind":"source_excerpt","locator":"Lines 78-84","start_line":78,"end_line":84,"excerpt":"## cla-oleate\nThis fat-cell result was not increased fat burning.\nAdding t10,c12 CLA reduced oleic-acid uptake and oxidation.\nModel: Primary cultures of differentiating human preadipocytes.\nLimitations: Does not determine whole-body fuel oxidation.\nEvidence access: Primary abstract\nIsomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12730300/ · DOI 10.1194/jlr.M300001-JLR200","model_system":"Primary cultures of differentiating human preadipocytes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f9fe73a8a4008d52061c65abe6de7a9806da75f1c478c5adace9387b8ffaad9e","revision_id":"21196d9c-aaab-5fe1-8f32-2987c94289c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}