{"id":"1371cd91-a6ab-507f-84c3-4726fcf2d490","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-slc15a4-mouse-cytokines","predicate":"supports","statement":"Mouse experiments attributed TLR-triggered cytokine production to functional Slc15a4 transport and linked Slc15a4 loss with reduced pathogenic antibody production.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4e3cbbd8-d3e3-54e4-b91c-71dfa6bcb5d7","mechanism_event_label":"The original model linked transporter function with the immune response.","subject":{"id":"6ec79306-1983-566c-8dd0-b100a18afc9e","slug":"mouse-slc15a4","display_name":"Mouse peptide/histidine transporter Pht1 / Slc15a4","entity_type_key":"protein"},"object":{"id":"dcdb18c2-ea1c-57c6-b4d0-cab37a20a852","slug":"mouse-b-cell-tlr7-cytokines","display_name":"TLR7-induced interferon and antibody output in mouse B cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4e3cbbd8-d3e3-54e4-b91c-71dfa6bcb5d7","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-slc15a4-mouse-cytokines-event","event_type":"observed_relationship","label":"The original model linked transporter function with the immune response.","description":"Mouse experiments attributed TLR-triggered cytokine production to functional Slc15a4 transport and linked Slc15a4 loss with reduced pathogenic antibody production.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6ec79306-1983-566c-8dd0-b100a18afc9e","slug":"mouse-slc15a4","display_name":"Mouse peptide/histidine transporter Pht1 / Slc15a4","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dcdb18c2-ea1c-57c6-b4d0-cab37a20a852","slug":"mouse-b-cell-tlr7-cytokines","display_name":"TLR7-induced interferon and antibody output in mouse B cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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