{"id":"13599965-4016-5c62-9a03-47bd9be0d172","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-abetalipo-a-alone","predicate":"alone_does_not_arrest","statement":"The six-patient abetalipoproteinemia report noted that vitamin A alone had not prevented or arrested the retinal lesion, whereas long-term regimens including vitamin E modified its course.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b87c206d-3e38-54b7-9786-9ef332b972bd","mechanism_event_label":"In this transport disease, vitamin A alone did not substitute for the broader treatment that included vitamin E.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"46b54167-aa74-56f5-8df9-caa1827f00e3","slug":"retinal-function-in-abetalipoproteinemia","display_name":"Retinal function in abetalipoproteinemia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b87c206d-3e38-54b7-9786-9ef332b972bd","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-abetalipo-a-alone-event","event_type":"observed_intervention","label":"In this transport disease, vitamin A alone did not substitute for the broader treatment that included vitamin E.","description":"The six-patient abetalipoproteinemia report noted that vitamin A alone had not prevented or arrested the retinal lesion, whereas long-term regimens including vitamin E modified its course.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"role":"component_of_combined_treatment","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"46b54167-aa74-56f5-8df9-caa1827f00e3","slug":"retinal-function-in-abetalipoproteinemia","display_name":"Retinal function in abetalipoproteinemia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six-patient long-term abetalipoproteinemia case series","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Large oral vitamin E doses for 12–18 years alongside low-fat diet and other fat-soluble vitamins; exact dose absent from the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Uncontrolled co-treatment series; cannot isolate vitamin E effect or demonstrate nutrient synergy. Genetic lipid transport disease differs from simple low intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In this transport disease, vitamin A alone did not substitute for the broader treatment that included vitamin E.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-retina1986] Oral vitamin E supplements can prevent the retinopathy of abetalipoproteinaemia. (1986). https://pubmed.ncbi.nlm.nih.gov/3954973/ DOI: 10.1136/bjo.70.3.166","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Retina","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"795181ef-bf61-585d-8957-5b15ae7edcde","evidence_kind":"source_excerpt","locator":"Lines 1453-1464","start_line":1453,"end_line":1464,"excerpt":"### e-clin-abetalipo-a-alone\nThe six-patient abetalipoproteinemia report noted that vitamin A alone had not prevented or arrested the retinal lesion, whereas long-term regimens including vitamin E modified its course.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: In this transport disease, vitamin A alone did not substitute for the broader treatment that included vitamin E.\norganism: Homo sapiens\ntissue_or_cell_type: Retina\nexperimental_model: Six-patient long-term abetalipoproteinemia case series\nlimitations: Uncontrolled co-treatment series; cannot isolate vitamin E effect or demonstrate nutrient synergy. Genetic lipid transport disease differs from simple low intake.\nexposure: Large oral vitamin E doses for 12–18 years alongside low-fat diet and other fat-soluble vitamins; exact dose absent from the abstract.\ncross_nutrient: true\n[e-clin-retina1986] Oral vitamin E supplements can prevent the retinopathy of abetalipoproteinaemia. (1986). https://pubmed.ncbi.nlm.nih.gov/3954973/ DOI: 10.1136/bjo.70.3.166","model_system":"Six-patient long-term abetalipoproteinemia case series","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-retina1986] Oral vitamin E supplements can prevent the retinopathy of abetalipoproteinaemia. (1986). https://pubmed.ncbi.nlm.nih.gov/3954973/ DOI: 10.1136/bjo.70.3.166","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}