{"id":"13562062-46d5-5612-9034-62261be971cb","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-transamination-human-abat","predicate":"transaminates","statement":"Recombinant human ABAT efficiently transaminated beta-alanine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"68f82f2d-0e7f-558b-89be-3e22740e8831","mechanism_event_label":"A competing enzyme can divert the precursor away from peptide synthesis.","subject":{"id":"9ef4e03f-a3be-55c6-90cb-4db1381e340c","slug":"human-abat","display_name":"Human GABA transaminase / ABAT","entity_type_key":"protein"},"object":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"68f82f2d-0e7f-558b-89be-3e22740e8831","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-transamination-human-abat-event","event_type":"observed_relationship","label":"A competing enzyme can divert the precursor away from peptide synthesis.","description":"Recombinant human ABAT efficiently transaminated beta-alanine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9ef4e03f-a3be-55c6-90cb-4db1381e340c","slug":"human-abat","display_name":"Human GABA transaminase / ABAT","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human enzyme expressed in HEK293T cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No clinical effect of changing vitamin B6 intake was established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A competing enzyme can divert the precursor away from peptide synthesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Carnosine and anserine homeostasis in skeletal muscle and heart is controlled by β-alanine transamination. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27062388/ · DOI 10.1113/JP272050","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e5dda314-2ddb-5c9f-b6be-dfc1471bf4cc","evidence_kind":"source_excerpt","locator":"Lines 124-130","start_line":124,"end_line":130,"excerpt":"## carnosine-transamination-human-abat\nA competing enzyme can divert the precursor away from peptide synthesis.\nRecombinant human ABAT efficiently transaminated beta-alanine.\nModel: Human enzyme expressed in HEK293T cells.\nLimitations: No clinical effect of changing vitamin B6 intake was established.\nEvidence access: Primary abstract\nCarnosine and anserine homeostasis in skeletal muscle and heart is controlled by β-alanine transamination. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27062388/ · DOI 10.1113/JP272050","model_system":"Human enzyme expressed in HEK293T cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"469cbc38203db56bd031f9d8a2dd2bfa387713950ca30199511cd137e927aa7a","revision_id":"cc409a15-8b04-50ee-a7ff-d1bf32f686bb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}