{"id":"131a1023-f0c1-5aa4-aec8-ef3858992bae","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-nact-lipids","predicate":"supports","statement":"Lithium increased NaCT-mediated use of extracellular citrate for lipid synthesis in human liver cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"43482321-fdcc-5997-8750-3d7dfcc2dfc1","mechanism_event_label":"Transported citrate can enter lipid-building pathways.","subject":{"id":"68eeb90a-bbc5-5bc8-8346-31029ed0d815","slug":"slc13a5","display_name":"Human sodium-coupled citrate transporter / SLC13A5","entity_type_key":"protein"},"object":{"id":"0bdb87d9-d1a0-5ae7-afce-4f9552991109","slug":"human-liver-cell-citrate-lipid-synthesis","display_name":"Human liver-cell extracellular-citrate incorporation into lipids","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"43482321-fdcc-5997-8750-3d7dfcc2dfc1","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-nact-lipids-event","event_type":"observed_relationship","label":"Transported citrate can enter lipid-building pathways.","description":"Lithium increased NaCT-mediated use of extracellular citrate for lipid synthesis in human liver cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"68eeb90a-bbc5-5bc8-8346-31029ed0d815","slug":"slc13a5","display_name":"Human sodium-coupled citrate transporter / SLC13A5","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0bdb87d9-d1a0-5ae7-afce-4f9552991109","slug":"human-liver-cell-citrate-lipid-synthesis","display_name":"Human liver-cell extracellular-citrate incorporation into lipids","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"1c54abac-4dfd-5303-b0f4-37945245e18e","slug":"citrate","display_name":"Citrate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human liver-cell tracer/transport study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish that this pathway explains clinical weight change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Transported citrate can enter lipid-building pathways.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12826022/ · DOI 10.1042/BJ20030827","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8c28a0c9-c8b7-502e-9211-7adc9ffece79","evidence_kind":"source_excerpt","locator":"Lines 272-278","start_line":272,"end_line":278,"excerpt":"## lithium-nact-lipids\nTransported citrate can enter lipid-building pathways.\nLithium increased NaCT-mediated use of extracellular citrate for lipid synthesis in human liver cells.\nModel: Human liver-cell tracer/transport study.\nLimitations: Does not establish that this pathway explains clinical weight change.\nEvidence access: Primary abstract\nHuman sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12826022/ · DOI 10.1042/BJ20030827","model_system":"Human liver-cell tracer/transport study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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