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The reaction is reversible; direction depends on conditions. Primary structural/biochemical work distinguishes NADP-specific AroE from paralog YdiB, which accepts NAD or NADP and has quinate/shikimate dehydrogenase activity. Do not give every homolog identical cofactor specificity or infer that human niacin supplementation necessarily increases gut pathway flux. [Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities.](https://pubmed.ncbi.nlm.nih.gov/12637497/) [Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose-xylose co-substrate.](https://pubmed.ncbi.nlm.nih.gov/31937786/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"320d1df4-8da0-5e1a-bb17-5140e264bf06","slug":"3-dehydroshikimate","display_name":"3-Dehydroshikimate / DHS","entity_type_key":"small_molecule"},"role":"input","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fe7a4dc3-4f06-586b-9457-2dd949e2fa36","slug":"shikimate","display_name":"Shikimate anion","entity_type_key":"small_molecule"},"role":"output","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6abc4184-d20e-5708-af26-b04fbbc4393f","slug":"ecoli-aroe","display_name":"Escherichia coli shikimate dehydrogenase / AroE","entity_type_key":"protein"},"role":"catalyst","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4aba2a5e-8d06-5304-bb01-c0402b225a94","slug":"nadph","display_name":"NADPH","entity_type_key":"small_molecule"},"role":"input","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"be6e4670-953f-5a4e-97da-1e536a54e0e4","slug":"nadp-plus","display_name":"NADP+","entity_type_key":"small_molecule"},"role":"output","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract reviewed; full results, tables and supplements not independently extracted.\nPrimary full text retrieved; relevant methods/results/figures reviewed. 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Do not give every homolog identical cofactor specificity or infer that human niacin supplementation necessarily increases gut pathway flux. [Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities.](https://pubmed.ncbi.nlm.nih.gov/12637497/) [Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose-xylose co-substrate.](https://pubmed.ncbi.nlm.nih.gov/31937786/)","model_system":"Escherichia coli biochemical pathway; source-specific enzyme evidence recorded in the passage.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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