{"id":"12bcde38-e109-541c-b616-192494410483","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-isomer-half-life","predicate":"had_shorter","statement":"All-trans tracer half-life was 5.3 ± 0.3 days versus 8.8 ± 0.6 days for cis isomers.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e20a625c-001c-5fbc-8b5b-c3f53e342292","mechanism_event_label":"Different forms remain in circulation for different lengths of time.","subject":{"id":"4a88840d-be05-5442-9938-a1da9df4d385","slug":"all-trans-lycopene","display_name":"All-trans-lycopene / all-E-lycopene","entity_type_key":"small_molecule"},"object":{"id":"92955d6f-3fa1-5694-8862-bd22847657b5","slug":"lycopene-plasma-half-life","display_name":"Plasma lycopene isomer half-life","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e20a625c-001c-5fbc-8b5b-c3f53e342292","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-isomer-half-life-event","event_type":"biochemical_relationship","label":"Different forms remain in circulation for different lengths of time.","description":"All-trans tracer half-life was 5.3 ± 0.3 days versus 8.8 ± 0.6 days for cis isomers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1b29c26f-bf19-50e4-a54a-b34b69f9060d","slug":"lycopene-cis-isomer-pool","display_name":"Study-specified cis-lycopene isomer pool","entity_type_key":"chemical_species"},"role":"isomer_pool","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4a88840d-be05-5442-9938-a1da9df4d385","slug":"all-trans-lycopene","display_name":"All-trans-lycopene / all-E-lycopene","entity_type_key":"small_molecule"},"role":"isomer","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"92955d6f-3fa1-5694-8862-bd22847657b5","slug":"lycopene-plasma-half-life","display_name":"Plasma lycopene isomer half-life","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/26561629.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682\", \"start_char\": 0, \"end_char\": 2207, \"text_sha256\": \"fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Stable-isotope tracer and seven-compartment kinetic modeling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"10.2 mg carbon-13 lycopene, 82% all-trans and 18% cis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small study; model-dependent pool estimates; formulation differs from food-matrix comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, eight healthy adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Different forms remain in circulation for different lengths of time.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p26561629] Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. (2015). https://pubmed.ncbi.nlm.nih.gov/26561629/ DOI: 10.3945/ajcn.114.103143","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma over 28 days and modeled tissue pools","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f8eb2416-5b22-53ed-8a09-bdc2d816038f","evidence_kind":"source_excerpt","locator":"Lines 234-245","start_line":234,"end_line":245,"excerpt":"### lycopene-isomer-half-life\nAll-trans tracer half-life was 5.3 ± 0.3 days versus 8.8 ± 0.6 days for cis isomers.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Different forms remain in circulation for different lengths of time.\norganism: Human, eight healthy adults\ntissue_or_cell_type: Plasma over 28 days and modeled tissue pools\nexperimental_model: Stable-isotope tracer and seven-compartment kinetic modeling\nlimitations: Small study; model-dependent pool estimates; formulation differs from food-matrix comparisons.\nexposure: 10.2 mg carbon-13 lycopene, 82% all-trans and 18% cis\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/26561629.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682\", \"start_char\": 0, \"end_char\": 2207, \"text_sha256\": \"fdc01c055cd2de5fc7523b3a3f4486ea939d5d197aaf214000328194f9586682\"}\n[lycopene-p26561629] Compartmental and noncompartmental modeling of ¹³C-lycopene absorption, isomerization, and distribution kinetics in healthy adults. 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