{"id":"12b01c93-95d7-504c-b8ce-31227a2d92ff","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-thyroid-clinical","predicate":"modifies","statement":"In a six-month trial of 50 women on fixed TSH-suppressive thyroxine, 2 or 4 g/day carnitine reduced or limited several hyperthyroid symptoms during treatment periods.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f60f2a36-0983-5966-9dcb-61329cee2e0c","mechanism_event_label":"A small clinical trial tested peripheral thyroid-hormone effects.","subject":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"object":{"id":"5e40623d-b525-5aa5-a109-5fa7f808603e","slug":"human-t4-suppression-symptoms","display_name":"Human thyroxine-induced hyperthyroid symptoms","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f60f2a36-0983-5966-9dcb-61329cee2e0c","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-thyroid-clinical-event","event_type":"observed_relationship","label":"A small clinical trial tested peripheral thyroid-hormone effects.","description":"In a six-month trial of 50 women on fixed TSH-suppressive thyroxine, 2 or 4 g/day carnitine reduced or limited several hyperthyroid symptoms during treatment periods.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5e40623d-b525-5aa5-a109-5fa7f808603e","slug":"human-t4-suppression-symptoms","display_name":"Human thyroxine-induced hyperthyroid symptoms","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f2b25f38-ec94-57d0-a46d-dd0fee45f01e","slug":"thyroxine","display_name":"T4","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Five groups of ten; randomized, double-blind placebo-controlled treatment periods.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Specific iatrogenic hyperthyroidism context; does not justify changing thyroid medication or establish universal safety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A small clinical trial tested peripheral thyroid-hormone effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11502782/ · DOI 10.1210/jcem.86.8.7747","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5ccde7b4-bb7b-5b62-b389-78aec52d966a","evidence_kind":"source_excerpt","locator":"Lines 306-312","start_line":306,"end_line":312,"excerpt":"## l-carnitine-thyroid-clinical\nA small clinical trial tested peripheral thyroid-hormone effects.\nIn a six-month trial of 50 women on fixed TSH-suppressive thyroxine, 2 or 4 g/day carnitine reduced or limited several hyperthyroid symptoms during treatment periods.\nModel: Five groups of ten; randomized, double-blind placebo-controlled treatment periods.\nLimitations: Specific iatrogenic hyperthyroidism context; does not justify changing thyroid medication or establish universal safety.\nEvidence access: Primary abstract\nUsefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11502782/ · DOI 10.1210/jcem.86.8.7747","model_system":"Five groups of ten; randomized, double-blind placebo-controlled treatment periods.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2c9c42b-806a-55e2-abde-b0320ea94704","stable_key":"import-6cdb37aa-8998-5ea8-829d-4f995caf98fc","title":"L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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