{"id":"124929b3-91b2-550a-b606-03f11bd41c1a","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-suox-persulfides","predicate":"loss_increases","statement":"SUOX-deficient cells accumulated persulfidated glutathione and cysteine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"92ce3d33-76b9-54d8-a491-36d972621e6a","mechanism_event_label":"Glutathione and cysteine sulfur chemistry also changed.","subject":{"id":"bf313203-7930-5d8b-9c8c-a10559dafcaf","slug":"suox","display_name":"Human sulfite oxidase / SUOX","entity_type_key":"protein"},"object":{"id":"26970c62-0910-5d32-85c7-aa08c4f624e8","slug":"glutathione-persulfide","display_name":"Glutathione persulfide / GSSH","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"92ce3d33-76b9-54d8-a491-36d972621e6a","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-suox-persulfides-event","event_type":"biochemical_relationship","label":"Glutathione and cysteine sulfur chemistry also changed.","description":"SUOX-deficient cells accumulated persulfidated glutathione and cysteine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0685d7c6-76f8-5d43-9a11-e2fc8ab5f714","slug":"cysteine-persulfide","display_name":"Cysteine persulfide / CysSSH","entity_type_key":"small_molecule"},"role":"associated product","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"precursor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"precursor","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bf313203-7930-5d8b-9c8c-a10559dafcaf","slug":"suox","display_name":"Human sulfite oxidase / SUOX","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"26970c62-0910-5d32-85c7-aa08c4f624e8","slug":"glutathione-persulfide","display_name":"Glutathione persulfide / GSSH","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/33271457.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"619710a31160db0927e01193e458277773ebe5e5423629e7dab58888ab6bc617\", \"start_char\": 0, \"end_char\": 1479, \"text_sha256\": \"619710a31160db0927e01193e458277773ebe5e5423629e7dab58888ab6bc617\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"CRISPR SUOX/GOT1/GOT2 perturbations and sulfur-metabolite assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cysteine-sulfinate and H2S pathway experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell-specific contributions; a higher concentration is not a direct measurement of pathway flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Glutathione and cysteine sulfur chemistry also changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p33271457] The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H<sub>2</sub>S metabolism. 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