{"id":"121113a8-34e0-5401-9b2e-4fcd31c94fc5","stable_key":"research:ferroptosis-waves","predicate":"can_propagate_as","statement":"Ferroptotic death propagated in the studied cell cultures and embryonic avian tissue.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"context_dependent","is_public":true,"mechanism_event_id":"7f86b6fe-6d0a-5931-941d-b579660b0a84","mechanism_event_label":"Researchers have experimentally studied spreading ferroptotic death.","subject":{"id":"85ca0bb8-8a67-59fe-8334-e0f6617380b7","slug":"ferroptosis","display_name":"Ferroptosis","entity_type_key":"cellular_process"},"object":{"id":"cd11ee39-9507-58d4-b636-b0a2c5aed190","slug":"ferroptosis-propagation","display_name":"propagation of ferroptotic cell death","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7f86b6fe-6d0a-5931-941d-b579660b0a84","stable_key":"research:ferroptosis-waves","event_type":"contextual_mechanism","label":"Researchers have experimentally studied spreading ferroptotic death.","description":"Ferroptotic death propagated in the studied cell cultures and embryonic avian tissue.","status":"active","compartment":null,"participants":[{"entity":{"id":"85ca0bb8-8a67-59fe-8334-e0f6617380b7","slug":"ferroptosis","display_name":"Ferroptosis","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cd11ee39-9507-58d4-b636-b0a2c5aed190","slug":"ferroptosis-propagation","display_name":"propagation of ferroptotic cell death","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"Studied cultures/tissue","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cultured cells and embryonic avian tissue","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not validate all combustion analogies, numerical thresholds or dietary selenium effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Mammalian cell cultures and embryonic avian tissue","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2320bc81-f23e-5d5e-9996-57f0dd8ac337","evidence_kind":"curated_literature_summary","locator":"lines 1480-1490","start_line":1480,"end_line":1490,"excerpt":"## ferroptosis-waves\n\nResearchers have experimentally studied spreading ferroptotic death.\n\nFerroptotic death propagated in the studied cell cultures and embryonic avian tissue.\n\nOrganism: Mammalian cell cultures and embryonic avian tissue\nCell type: Studied cultures/tissue\nExperimental model: Cultured cells and embryonic avian tissue\nLimitations: Does not validate all combustion analogies, numerical thresholds or dietary selenium effects.\nPrimary reference: [Emergence of large-scale cell death through ferroptotic trigger waves](https://www.nature.com/articles/s41586-024-07623-6)","model_system":"Cultured cells and embryonic avian tissue","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[{"id":"a1db4054-8954-5937-a837-6404c11276fd","title":"Propagating ferroptosis has been studied experimentally","kind":"qualification","status":"qualified","why":"The nobody-has-looked novelty claim is outdated by direct collective-cell-death research.","resolution":"Link existing experiments without promoting every combustion analogy or threshold to fact.","created_at":"2026-09-17 07:19:34","record_type":"qualification","display_label":"Source qualification","record_url":"/corrections/a1db4054-8954-5937-a837-6404c11276fd","literature_review":{"revision_id":"80984e03-5f0f-5877-8094-afef7637444e","start_line":1725,"end_line":1730,"papers":[{"paper_key":"co-2024","title":"Emergence of large-scale cell death through ferroptotic trigger waves","url":"https://www.nature.com/articles/s41586-024-07623-6","doi":"10.1038/s41586-024-07623-6","year":2024,"model":"Cultured cells and embryonic avian tissue","summary":"Directly studies propagation of ferroptotic death; not all combustion analogies."}]},"sides":[{"conflict_id":"a1db4054-8954-5937-a837-6404c11276fd","ordinal":0,"label":"Original preserved statement","revision_id":"4cec6304-35d7-5560-9133-e6ea689db838","start_line":436,"end_line":436,"quote":"The Semenov framing predicts things the biochemical framing doesn't: hysteresis, ignition delay, propagation between adjacent cells, and a critical *size* below which a membrane patch can't sustain a chain. **Nobody has looked for ferroptotic wave propagation across a tissue** the way you'd look for a flame front. Given that ferroptosis spreads cell-to-cell in a wave-like manner in culture (documented, unexplained), that framing may already be the right one.","claim_id":null,"source_key":"corrections","source_title":"Selenium corrections and deep dive","claim_ids":[]},{"conflict_id":"a1db4054-8954-5937-a837-6404c11276fd","ordinal":1,"label":"Literature correction and experimental limits","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","start_line":1725,"end_line":1730,"quote":"## Propagating ferroptosis has been studied experimentally\n\nThe nobody-has-looked novelty claim is outdated by direct collective-cell-death research.\n\nLink existing experiments without promoting every combustion analogy or threshold to fact.\nPrimary reference: [Emergence of large-scale cell death through ferroptotic trigger waves](https://www.nature.com/articles/s41586-024-07623-6)","claim_id":null,"source_key":"selenium-research-2026-09-17","source_title":"Selenium: literature corrections and mechanism additions","claim_ids":[]}]}],"research":{"topic":"Selenium scientific audit","plain_language":"Researchers have experimentally studied spreading ferroptotic death.","evidence_scope":"direct_experimental","papers":[{"key":"co-2024","title":"Emergence of large-scale cell death through ferroptotic trigger waves","url":"https://www.nature.com/articles/s41586-024-07623-6","doi":"10.1038/s41586-024-07623-6","year":2024,"model":"Cultured cells and embryonic avian tissue","summary":"Directly studies propagation of ferroptotic death; not all combustion analogies."}]}}