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it was not RXR-selective.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An RXR-binding retinoid can also activate RAR pathways.\norganism: Recombinant receptors in COS-1 cells\ntissue_or_cell_type: Nuclear extracts\nexperimental_model: Transfected COS-1 nucleosol; ligand competition and chimeric receptor reporters.\nlimitations: Does not establish endogenous tissue concentrations.\nevidence_locator: Abstract\nexposure: Isomer competition\n[va-allenby-1993] Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids (1993). https://pubmed.ncbi.nlm.nih.gov/8380496/ DOI: 10.1073/pnas.90.1.30","model_system":"Transfected COS-1 nucleosol; ligand competition and chimeric receptor reporters.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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