{"id":"11e09730-b75e-5b3f-8924-fd6b8d6f1bd4","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-absorption-estimate","predicate":"has_low_urinary_recovery","statement":"Daily urinary recovery was roughly 1% or less of administered elemental V in the trial, used by the authors to estimate low oral absorption.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b70e8f4a-5719-578c-be68-d771b48293da","mechanism_event_label":"Only a small fraction of the oral dose appeared in urine each day.","subject":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"object":{"id":"a7781fea-5a98-5892-a4f9-c13ff8691b9b","slug":"human-vanadium-urinary-recovery","display_name":"Urinary recovery of orally administered vanadium","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b70e8f4a-5719-578c-be68-d771b48293da","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-absorption-estimate-event","event_type":"observed_relationship","label":"Only a small fraction of the oral dose appeared in urine each day.","description":"Daily urinary recovery was roughly 1% or less of administered elemental V in the trial, used by the authors to estimate low oral absorption.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a7781fea-5a98-5892-a4f9-c13ff8691b9b","slug":"human-vanadium-urinary-recovery","display_name":"Urinary recovery of orally administered vanadium","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same cohort; steady-state urine measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The full text calls this a minimum absorption estimate because tissue accumulation and other compartments can matter; do not present it as complete mass balance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Only a small fraction of the oral dose appeared in urine each day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23982218/ · DOI 10.1039/c3mt00162h","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4bf38923-46c4-56f1-a066-e5b00e2f3384","evidence_kind":"source_excerpt","locator":"Lines 430-436","start_line":430,"end_line":436,"excerpt":"## vanadium-human-absorption-estimate\nOnly a small fraction of the oral dose appeared in urine each day.\nDaily urinary recovery was roughly 1% or less of administered elemental V in the trial, used by the authors to estimate low oral absorption.\nModel: Same cohort; steady-state urine measurements.\nLimitations: The full text calls this a minimum absorption estimate because tissue accumulation and other compartments can matter; do not present it as complete mass balance.\nEvidence access: Primary full text\nCoordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23982218/ · DOI 10.1039/c3mt00162h","model_system":"Same cohort; steady-state urine measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"d36b30d972e756ca4d19b66f976980e206c65025bd4bbf4c127c17320bd019c2","revision_id":"70d42967-8032-5627-8670-f59841735e89","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}