{"id":"11c12165-43d1-5bfe-b725-2f3f435e48fd","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-repletion-iron-store-redistribution","predicate":"changes","statement":"Ferritin fell while calculated total-body iron remained unchanged in the same trial, consistent with redistribution of existing iron.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5ec36fa0-0d72-5dce-950a-b5edb43bf56c","mechanism_event_label":"A better blood count did not require a measured increase in total-body iron.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"9b302959-20f9-5764-9635-793e8435e278","slug":"serum-ferritin-concentration","display_name":"Serum ferritin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5ec36fa0-0d72-5dce-950a-b5edb43bf56c","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-repletion-iron-store-redistribution-event","event_type":"observed_intervention","label":"A better blood count did not require a measured increase in total-body iron.","description":"Ferritin fell while calculated total-body iron remained unchanged in the same trial, consistent with redistribution of existing iron.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"redistributed_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"29e90df8-316c-5bee-8f28-438efca8a857","slug":"calculated-body-iron-stores","display_name":"Calculated whole-body iron stores","entity_type_key":"cellular_process"},"role":"modelled_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9b302959-20f9-5764-9635-793e8435e278","slug":"serum-ferritin-concentration","display_name":"Serum ferritin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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liver iron was not directly biopsied.\n[va-zimmermann2006-iron] Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron (2006). https://pubmed.ncbi.nlm.nih.gov/16960172/ DOI: 10.1093/ajcn/84.3.580","model_system":"Ferritin/transferrin-receptor-based estimates.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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