{"id":"11c0cfa7-e7ae-5229-aa8f-80aba487808e","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-bco2-regional","predicate":"shows_regional_abundance_in","statement":"Human donor retina had higher BCO2 protein expression peripherally than centrally.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2d0f9ee2-a141-5c02-9df6-7f78db9f4691","mechanism_event_label":"The breakdown enzyme was unevenly distributed across the retina.","subject":{"id":"6bafd6da-3aef-56c9-8402-24a93bb91c92","slug":"human-bco2","display_name":"Human beta-carotene oxygenase 2 / BCO2","entity_type_key":"protein"},"object":{"id":"da49f914-914a-5e7f-9dba-822de5c4c7d7","slug":"human-bco2-retinal-expression","display_name":"Human retinal BCO2 regional protein abundance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2d0f9ee2-a141-5c02-9df6-7f78db9f4691","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-bco2-regional-event","event_type":"biochemical_relationship","label":"The breakdown enzyme was unevenly distributed across the retina.","description":"Human donor retina had higher BCO2 protein expression peripherally than centrally.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6bafd6da-3aef-56c9-8402-24a93bb91c92","slug":"human-bco2","display_name":"Human beta-carotene oxygenase 2 / BCO2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"da49f914-914a-5e7f-9dba-822de5c4c7d7","slug":"human-bco2-retinal-expression","display_name":"Human retinal BCO2 regional protein abundance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/39978586.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3546acef9586e54733ec1f03797741c67643606de59f80a7762815b32c3c03fe\", \"start_char\": 0, \"end_char\": 1561, \"text_sha256\": \"3546acef9586e54733ec1f03797741c67643606de59f80a7762815b32c3c03fe\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Validated antibodies, localization, donor-retina analysis and activity assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"BCO2 precursor/processed protein comparison; Aster interactions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Protein expression and interaction evidence does not by itself quantify lutein cleavage in living human retina.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human cells/donor retina and macaque retina","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The breakdown enzyme was unevenly distributed across the retina.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p39978586] Unveiling BCO2 function in macular pigment metabolism: Mitochondrial processing and expression in the primate retina. (2025). https://pubmed.ncbi.nlm.nih.gov/39978586/ DOI: 10.1016/j.bbalip.2025.159600","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Retinal regions and mitochondria","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7b18db8b-9033-5e9f-b4dc-dd0cb68f9a12","evidence_kind":"source_excerpt","locator":"Lines 333-344","start_line":333,"end_line":344,"excerpt":"### lutein-bco2-regional\nHuman donor retina had higher BCO2 protein expression peripherally than centrally.\nCondition category: normal\nnutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The breakdown enzyme was unevenly distributed across the retina.\norganism: Human cells/donor retina and macaque retina\ntissue_or_cell_type: Retinal regions and mitochondria\nexperimental_model: Validated antibodies, localization, donor-retina analysis and activity assays\nlimitations: Protein expression and interaction evidence does not by itself quantify lutein cleavage in living human retina.\nexposure: BCO2 precursor/processed protein comparison; Aster interactions\nevidence_span: {\"source_cache\": \"artifacts/lutein-research/39978586.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3546acef9586e54733ec1f03797741c67643606de59f80a7762815b32c3c03fe\", \"start_char\": 0, \"end_char\": 1561, \"text_sha256\": \"3546acef9586e54733ec1f03797741c67643606de59f80a7762815b32c3c03fe\"}\n[lutein-p39978586] Unveiling BCO2 function in macular pigment metabolism: Mitochondrial processing and expression in the primate retina. 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