{"id":"11b7de84-1f6f-5dab-af6a-0edfd2f69ef2","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-renal-loading-washout","predicate":"reverses","statement":"Growth-plate and osteoid abnormalities associated with strontium loading reversed after washout in the renal-failure rat study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bd957013-80f6-5fca-b587-dbbb1cab56c2","mechanism_event_label":"Removing the exposure reversed the measured injury in this model.","subject":{"id":"d90a5498-87b0-5afb-a466-4073e3fbabb4","slug":"rat-strontium-washout","display_name":"Strontium washout in renal-failure rats","entity_type_key":"cellular_process"},"object":{"id":"1fd33465-4d73-5020-a915-df8631431618","slug":"rat-renal-failure-strontium-rickets","display_name":"Rickets during strontium loading in rats with chronic renal failure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bd957013-80f6-5fca-b587-dbbb1cab56c2","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-renal-loading-washout-event","event_type":"observed_relationship","label":"Removing the exposure reversed the measured injury in this model.","description":"Growth-plate and osteoid abnormalities associated with strontium loading reversed after washout in the renal-failure rat study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d90a5498-87b0-5afb-a466-4073e3fbabb4","slug":"rat-strontium-washout","display_name":"Strontium washout in renal-failure rats","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1fd33465-4d73-5020-a915-df8631431618","slug":"rat-renal-failure-strontium-rickets","display_name":"Rickets during strontium loading in rats with chronic renal failure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Two- to eight-week washout periods after loading.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reversibility in rats does not establish a human treatment protocol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Removing the exposure reversed the measured injury in this model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Moderate strontium loading induces rickets in rats with mild chronic renal failure. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21654178/ · DOI 10.1159/000328329","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c3337081-4ef6-5be0-a28e-4a90aef8e13a","evidence_kind":"source_excerpt","locator":"Lines 334-340","start_line":334,"end_line":340,"excerpt":"## strontium-renal-loading-washout\nRemoving the exposure reversed the measured injury in this model.\nGrowth-plate and osteoid abnormalities associated with strontium loading reversed after washout in the renal-failure rat study.\nModel: Two- to eight-week washout periods after loading.\nLimitations: Reversibility in rats does not establish a human treatment protocol.\nEvidence access: Primary abstract\nModerate strontium loading induces rickets in rats with mild chronic renal failure. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21654178/ · DOI 10.1159/000328329","model_system":"Two- to eight-week washout periods after loading.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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