{"id":"11b0ed52-ed77-5775-8b4d-ca8c1c36cd02","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-xanthin-stiffness-null","predicate":"no_detected_effect","statement":"XANTHIN randomized 61 renal-transplant recipients to 12 mg/day astaxanthin or placebo for one year and found no effect on arterial stiffness.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"cb406be1-1ef0-55a5-aaaf-4e068953a472","mechanism_event_label":"A longer clinical trial did not reproduce the expected vascular benefit.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"475a2c80-af3d-5308-b215-c7944bb40c66","slug":"human-astaxanthin-arterial-stiffness","display_name":"Human arterial stiffness after astaxanthin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cb406be1-1ef0-55a5-aaaf-4e068953a472","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-xanthin-stiffness-null-event","event_type":"observed_relationship","label":"A longer clinical trial did not reproduce the expected vascular benefit.","description":"XANTHIN randomized 61 renal-transplant recipients to 12 mg/day astaxanthin or placebo for one year and found no effect on arterial stiffness.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"475a2c80-af3d-5308-b215-c7944bb40c66","slug":"human-astaxanthin-arterial-stiffness","display_name":"Human arterial stiffness after astaxanthin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human randomized trial; 58 completed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Population and endpoint differ from cell and healthy-volunteer studies; variability limited power.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A longer clinical trial did not reproduce the expected vascular benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial). · 2016 · https://pubmed.ncbi.nlm.nih.gov/26675778/ · DOI 10.3945/ajcn.115.115477","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"65d62813-5aed-53a1-9ea6-42fd7f2fb3c8","evidence_kind":"source_excerpt","locator":"Lines 430-436","start_line":430,"end_line":436,"excerpt":"## astaxanthin-xanthin-stiffness-null\nA longer clinical trial did not reproduce the expected vascular benefit.\nXANTHIN randomized 61 renal-transplant recipients to 12 mg/day astaxanthin or placebo for one year and found no effect on arterial stiffness.\nModel: Human randomized trial; 58 completed.\nLimitations: Population and endpoint differ from cell and healthy-volunteer studies; variability limited power.\nEvidence access: Primary abstract\nAstaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial). · 2016 · https://pubmed.ncbi.nlm.nih.gov/26675778/ · DOI 10.3945/ajcn.115.115477","model_system":"Human randomized trial; 58 completed.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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