{"id":"10af4b6c-bf18-5ad8-b7ee-dd3bbeec75f6","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-ggt-urine-high","predicate":"increases","statement":"Urinary GSH was about 2500-fold higher in Ggt1-null mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"97ee327d-5340-5ea7-be74-e8aa031f0c35","mechanism_event_label":"Glutathione was lost rather than effectively salvaged.","subject":{"id":"86512d80-f134-5af3-a717-de346e193792","slug":"mouse-ggt1-null","display_name":"Ggt1-null mice in the 1996 study","entity_type_key":"protein_state"},"object":{"id":"8d1272b4-8f35-532b-93ee-5f3a8a1716ac","slug":"ggt-null-urinary-gsh","display_name":"Urinary glutathione excretion in Ggt1-null mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"97ee327d-5340-5ea7-be74-e8aa031f0c35","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-ggt-urine-high-event","event_type":"biochemical_relationship","label":"Glutathione was lost rather than effectively salvaged.","description":"Urinary GSH was about 2500-fold higher in Ggt1-null mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"86512d80-f134-5af3-a717-de346e193792","slug":"mouse-ggt1-null","display_name":"Ggt1-null mice in the 1996 study","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8d1272b4-8f35-532b-93ee-5f3a8a1716ac","slug":"ggt-null-urinary-gsh","display_name":"Urinary glutathione excretion in Ggt1-null mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/glutathione-research/8755578.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"94d2520bc0124611c649d943ab9acd9cdf73cd3cb99d66640338a57bda6f6dfb\", \"start_char\": 0, \"end_char\": 1159, \"text_sha256\": \"94d2520bc0124611c649d943ab9acd9cdf73cd3cb99d66640338a57bda6f6dfb\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Targeted GGT gene disruption and NAC rescue","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ggt1-null versus wild type; oral NAC","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Severe genetic salvage defect; high extracellular GSH did not mean adequate tissue stores.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glutathione research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Glutathione was lost rather than effectively salvaged.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[glutathione-p8755578] Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice. 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