{"id":"1066a91b-756c-510e-a7da-b6531ceb5633","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-huvec-senolysis","predicate":"induces","statement":"Fisetin selectively induced apoptosis in senescent human HUVECs while sparing proliferating cells in the reported irradiation model.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"06bd7ac8-2a91-561d-9c64-9ee9781aeea3","mechanism_event_label":"Some senescent cells were selectively vulnerable.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"6e06aeda-9787-5558-a411-d23037ee01db","slug":"human-huvec-senescent-cell-apoptosis","display_name":"Apoptosis of senescent human HUVECs, induction specified","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"06bd7ac8-2a91-561d-9c64-9ee9781aeea3","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-huvec-senolysis-event","event_type":"observed_relationship","label":"Some senescent cells were selectively vulnerable.","description":"Fisetin selectively induced apoptosis in senescent human HUVECs while sparing proliferating cells in the reported irradiation model.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6e06aeda-9787-5558-a411-d23037ee01db","slug":"human-huvec-senescent-cell-apoptosis","display_name":"Apoptosis of senescent human HUVECs, induction specified","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human endothelial cultures; apoptosis and viability assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a demonstration of senescent-cell removal throughout a human body.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Some senescent cells were selectively vulnerable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28273655/ · DOI 10.18632/aging.101202","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4ea1ae17-ac17-57b2-89d4-01eca24f8d4c","evidence_kind":"source_excerpt","locator":"Lines 184-190","start_line":184,"end_line":190,"excerpt":"## fisetin-huvec-senolysis\nSome senescent cells were selectively vulnerable.\nFisetin selectively induced apoptosis in senescent human HUVECs while sparing proliferating cells in the reported irradiation model.\nModel: Human endothelial cultures; apoptosis and viability assays.\nLimitations: Not a demonstration of senescent-cell removal throughout a human body.\nEvidence access: Primary full text\nNew agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28273655/ · DOI 10.18632/aging.101202","model_system":"Human endothelial cultures; apoptosis and viability assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}