{"id":"1046ccb6-0163-57e2-b106-210705f4a92b","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-pth-null-2004","predicate":"did_not_change","statement":"The tested boron and magnesium dietary treatments did not significantly affect serum PTH in the 2004 study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3812fbca-a065-5322-b492-d50964d6646a","mechanism_event_label":"The study did not demonstrate that boron improves mineral balance by raising or lowering PTH.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"20086ed6-508d-540d-b23d-146f23a8990b","slug":"serum-pth-concentration","display_name":"Serum PTH concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3812fbca-a065-5322-b492-d50964d6646a","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-pth-null-2004-event","event_type":"observed_intervention","label":"The study did not demonstrate that boron improves mineral balance by raising or lowering PTH.","description":"The tested boron and magnesium dietary treatments did not significantly affect serum PTH in the 2004 study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"dietary_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"20086ed6-508d-540d-b23d-146f23a8990b","slug":"serum-pth-concentration","display_name":"Serum PTH concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/15724868.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24\", \"start_char\": 0, \"end_char\": 2138, \"text_sha256\": \"7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Approximately 118 versus 318 mg Mg/day and 0.25 versus 3.25 mg B/day; 42-day periods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Boron had no obvious overall effect on the response to magnesium deprivation. Results cannot establish boron as a treatment for hypomagnesemia or a substitute for magnesium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The study did not demonstrate that boron improves mineral balance by raising or lowering PTH.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mineral balance and endocrine measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"74f750dd-e5fc-5166-8a2e-c44b25f4e95f","evidence_kind":"source_excerpt","locator":"Lines 781-792","start_line":781,"end_line":792,"excerpt":"### boron-pth-null-2004\nThe tested boron and magnesium dietary treatments did not significantly affect serum PTH in the 2004 study.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The study did not demonstrate that boron improves mineral balance by raising or lowering PTH.\norganism: Human\ntissue_or_cell_type: Mineral balance and endocrine measurements\nexperimental_model: Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women\nlimitations: Boron had no obvious overall effect on the response to magnesium deprivation. Results cannot establish boron as a treatment for hypomagnesemia or a substitute for magnesium.\nexposure: Approximately 118 versus 318 mg Mg/day and 0.25 versus 3.25 mg B/day; 42-day periods\nevidence_span: {\"source_cache\": \"artifacts/boron-research/15724868.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24\", \"start_char\": 0, \"end_char\": 2138, \"text_sha256\": \"7009311021e781ba9b1e9a9244c081cf20700511cc8704e8294b1a2c55dc0e24\"}\n[boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/","model_system":"Double-blind Latin-square metabolic-unit feeding in 13 postmenopausal women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p15724868] The alteration of magnesium, calcium and phosphorus metabolism by dietary magnesium deprivation in postmenopausal women is not affected by dietary boron deprivation. (2004). https://pubmed.ncbi.nlm.nih.gov/15724868/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"0a32c1c5c70cfb4a378f6ace35cf5b75d90ed3065ada91b9f9f64015d603c8e3","revision_id":"38f316f2-4344-542e-a638-0ac5402f678d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}