{"id":"1039fbd1-0207-5330-bade-c0e59c65c9cd","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:ocular-distribution","predicate":"reported_relationship","statement":"Intact blackcurrant anthocyanins were detected in rat and rabbit ocular tissues after the reported oral or injected exposures.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"fc54983f-8585-5731-ba6c-c9b7f9b55973","mechanism_event_label":"Intact blackcurrant anthocyanins were detected in rat and rabbit ocular tissues after the reported oral or injected exposures.","subject":{"id":"208e948c-a7a4-5d34-8b16-81ec33dc7324","slug":"blackcurrant-anthocyanin-preparation","display_name":"Blackcurrant anthocyanin preparation in Matsumoto 2006","entity_type_key":"botanical"},"object":{"id":"6f3996dc-8aee-5b49-91b5-88ed0260bf11","slug":"rodent-rabbit-ocular-anthocyanin-distribution","display_name":"Intact anthocyanin detection in rat and rabbit ocular tissues","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fc54983f-8585-5731-ba6c-c9b7f9b55973","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:ocular-distribution-event","event_type":"experimental_observation","label":"Intact blackcurrant anthocyanins were detected in rat and rabbit ocular tissues after the reported oral or injected exposures.","description":"**Animal ocular delivery has been observed.** Blackcurrant anthocyanins were detected intact in rat and rabbit ocular tissues after the reported oral and injected administrations. Route and species matter: these experiments cannot establish a human retinal concentration after eating berries, an equivalence to vitamin A, or enhanced rhodopsin regeneration in people. [Matsumoto et al., 2006](https://pubmed.ncbi.nlm.nih.gov/16635490/).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"208e948c-a7a4-5d34-8b16-81ec33dc7324","slug":"blackcurrant-anthocyanin-preparation","display_name":"Blackcurrant anthocyanin preparation in Matsumoto 2006","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"6f3996dc-8aee-5b49-91b5-88ed0260bf11","slug":"rodent-rabbit-ocular-anthocyanin-distribution","display_name":"Intact anthocyanin detection in rat and rabbit ocular tissues","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract reviewed; full methods, figures, exact doses or endpoint-specific species assignments may remain unextracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rats: oral and intraperitoneal studies; rabbits: intravenous study. 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Route and species matter: these experiments cannot establish a human retinal concentration after eating berries, an equivalence to vitamin A, or enhanced rhodopsin regeneration in people. [Matsumoto et al., 2006](https://pubmed.ncbi.nlm.nih.gov/16635490/).","model_system":"Rats: oral and intraperitoneal studies; rabbits: intravenous study. Not equivalent routes or human exposures.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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