{"id":"10099cf5-d17e-540d-a383-9d27fb0e9f4c","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-impa-lithium","predicate":"inhibits_metal_dependent_activity","statement":"The human IMPase study supported lithium binding at the second metal site in its catalytic model.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"e7e9f42e-26ea-559c-8302-5d6a4b6fb928","mechanism_event_label":"Lithium can interrupt the recycling step.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"3f404867-317e-5b5c-92a7-9b6e0411dec3","slug":"impa1","display_name":"IMPA1 (human inositol monophosphatase 1)","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"e7e9f42e-26ea-559c-8302-5d6a4b6fb928","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-impa-lithium-event","event_type":"observed_relationship","label":"Lithium can interrupt the recycling step.","description":"The human IMPase study supported lithium binding at the second metal site in its catalytic model.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3f404867-317e-5b5c-92a7-9b6e0411dec3","slug":"impa1","display_name":"IMPA1 (human inositol monophosphatase 1)","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"73ca02b4-c78f-50b0-a8f2-97a7715150f7","slug":"inositol-monophosphates","display_name":"Inositol monophosphates","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human enzyme kinetics, fluorescence and structural modeling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Binding-site assignment is model-supported; treatment benefit is not established by enzyme inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Lithium can interrupt the recycling step.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Mechanism of inositol monophosphatase, the putative target of lithium therapy. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8016062/ · DOI 10.1073/pnas.91.13.5766","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d7f78858-0d57-5a18-8cdd-d4607a022c2b","evidence_kind":"source_excerpt","locator":"Lines 40-46","start_line":40,"end_line":46,"excerpt":"## lithium-impa-lithium\nLithium can interrupt the recycling step.\nThe human IMPase study supported lithium binding at the second metal site in its catalytic model.\nModel: Human enzyme kinetics, fluorescence and structural modeling.\nLimitations: Binding-site assignment is model-supported; treatment benefit is not established by enzyme inhibition.\nEvidence access: Primary abstract\nMechanism of inositol monophosphatase, the putative target of lithium therapy. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8016062/ · DOI 10.1073/pnas.91.13.5766","model_system":"Human enzyme kinetics, fluorescence and structural modeling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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