{"id":"0fad336e-5fdd-51fa-8ff6-edf6a441725f","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-tcell-methylation","predicate":"supports_tested","statement":"Methionine availability and induced transport supported protein synthesis, methionine-cycle flux and RNA/histone methylation in activated murine T cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ff522987-fe04-571f-92a6-2af020403827","mechanism_event_label":"The imported amino acid feeds both proteins and regulatory methyl marks.","subject":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"object":{"id":"54e9dd2d-b57b-5874-9957-8a7bec192018","slug":"mouse-tcell-methionine-cycle-methylation","display_name":"Methionine-cycle flux and RNA/histone methylation in mouse T cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ff522987-fe04-571f-92a6-2af020403827","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-tcell-methylation-event","event_type":"observed_relationship","label":"The imported amino acid feeds both proteins and regulatory methyl marks.","description":"Methionine availability and induced transport supported protein synthesis, methionine-cycle flux and RNA/histone methylation in activated murine T cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"54e9dd2d-b57b-5874-9957-8a7bec192018","slug":"mouse-tcell-methionine-cycle-methylation","display_name":"Methionine-cycle flux and RNA/histone methylation in mouse T cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6ba093a8-b28f-59dd-bdd0-732bb1f18c97","slug":"mouse-slc7a5","display_name":"Mouse LAT1 / Slc7a5","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Murine T-cell proteomics and metabolic labeling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish that more dietary methionine improves immunity in adequately nourished people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The imported amino acid feeds both proteins and regulatory methyl marks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antigen receptor control of methionine metabolism in T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30916644/ · DOI 10.7554/eLife.44210","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"abbdf594-a082-5d38-b239-c04f3f1069f5","evidence_kind":"source_excerpt","locator":"Lines 52-58","start_line":52,"end_line":58,"excerpt":"## methionine-tcell-methylation\nThe imported amino acid feeds both proteins and regulatory methyl marks.\nMethionine availability and induced transport supported protein synthesis, methionine-cycle flux and RNA/histone methylation in activated murine T cells.\nModel: Murine T-cell proteomics and metabolic labeling.\nLimitations: Does not establish that more dietary methionine improves immunity in adequately nourished people.\nEvidence access: Primary full text\nAntigen receptor control of methionine metabolism in T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30916644/ · DOI 10.7554/eLife.44210","model_system":"Murine T-cell proteomics and metabolic labeling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d969b004-ccc2-5bb4-9109-8ac649137ad1","stable_key":"import-41a89233-da9a-5b7b-9c18-e19bbadcfe2d","title":"L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f1c706ef72932eed85df234b6c3304158d503d626a63c69b02a453c162700d26","revision_id":"549035e0-3a72-550a-8a55-e8c5baa51b0d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}